Search Results

Overview

Uniprot IDP16662
Protein NameUDP-glucuronosyltransferase 2B7
Gene NameUGT2B7
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
128 DITRKFCKDVVSNKK
134 CKDVVSNKKFMKKVQ
343 LWRFDGNKPDTLGLN
367 NDLLGHPKTRAFITH
439 VINDPSYKENVMKLS
444 SYKENVMKLSRIQHD
455 IQHDQPVKPLDRAVF

Function

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:10702251, PubMed:15231852, PubMed:15470161, PubMed:15472229, PubMed:17442341, PubMed:18674515, PubMed:18719240, PubMed:19022937, PubMed:21422672, PubMed:23288867, PubMed:23756265, PubMed:26220143, PubMed:38211441, PubMed:9169006). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:15470161, PubMed:18674515, PubMed:23756265). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens) (PubMed:15472229, PubMed:17442341, PubMed:18719240, PubMed:19022937, PubMed:2159463, PubMed:23288867, PubMed:26220143, PubMed:9169006). Also regulates the levels of retinoic acid, a major metabolite of vitamin A involved in apoptosis, cellular growth and differentiation, and embryonic development (PubMed:10702251). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE, 20-HETE, PGE2, PGB1 and F2-isoprostanes (8-iso-PGF2alpha and 5-epi-5-F2t-IsoP) (PubMed:15231852, PubMed:38211441). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group (PubMed:21422672). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II (PubMed:18674515). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161)

Protein Sequence

10 MSVKWTSVIL 20 LIQLSFCFSS 30 GNCGKVLVWA 40 AEYSHWMNIK 50 TILDELIQRG 60 HEVTVLASSA 70 SILFDPNNSS 80 ALKIEIYPTS 90 LTKTELENFI 100 MQQIKRWSDL 110 PKDTFWLYFS 120 QVQEIMSIFG 130 DITRKFCKDV 140 VSNKKFMKKV 150 QESRFDVIFA 160 DAIFPCSELL 170 AELFNIPFVY 180 SLSFSPGYTF 190 EKHSGGFIFP 200 PSYVPVVMSE 210 LTDQMTFMER 220 VKNMIYVLYF 230 DFWFEIFDMK 240 KWDQFYSEVL 250 GRPTTLSETM 260 GKADVWLIRN 270 SWNFQFPYPL 280 LPNVDFVGGL 290 HCKPAKPLPK 300 EMEDFVQSSG 310 ENGVVVFSLG 320 SMVSNMTEER 330 ANVIASALAQ 340 IPQKVLWRFD 350 GNKPDTLGLN 360 TRLYKWIPQN 370 DLLGHPKTRA 380 FITHGGANGI 390 YEAIYHGIPM 400 VGIPLFADQP 410 DNIAHMKARG 420 AAVRVDFNTM 430 SSTDLLNALK 440 RVINDPSYKE 450 NVMKLSRIQH 460 DQPVKPLDRA 470 VFWIEFVMRH 480 KGAKHLRVAA 490 HDLTWFQYHS 500 LDVIGFLLVC 510 VATVIFIVTK 520 CCLFCFWKFA RKAKKGKND

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0016020 membrane
Molecular Function GO:0015020 glucuronosyltransferase activity
Biological Process GO:0008209 androgen metabolic process
Biological Process GO:0008210 estrogen metabolic process
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0006805 xenobiotic metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.