Search Results
Overview
| Uniprot ID | P16975 |
|---|---|
| Protein Name | SPARC |
| Gene Name | Sparc |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 189 | GNNLLTEKQKLRVKK |
Function
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity
Protein Sequence
10
MRAWIFFLLC
20
LAGRALAAPQ
30
TEAAEEMVAE
40
ETVVEETGLP
50
VGANPVQVEM
60
GEFEEGAEET
70
VEEVVAENPC
80
QNHHCKHGKV
90
CELDESNTPM
100
CVCQDPTSCP
110
APIGEFEKVC
120
SNDNKTFDSS
130
CHFFATKCTL
140
EGTKKGHKLH
150
LDYIGPCKYI
160
APCLDSELTE
170
FPLRMRDWLK
180
NVLVTLYERD
190
EGNNLLTEKQ
200
KLRVKKIHEN
210
EKRLEAGDHP
220
VELLARDFEK
230
NYNMYIFPVH
240
WQFGQLDQHP
250
IDGYLSHTEL
260
APLRAPLIPM
270
EHCTTRFFET
280
CDLDNDKYIA
290
LEEWAGCFGI
300
KEQDINKDLV
I
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005604 | basement membrane |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0031091 | platelet alpha granule |
| Cellular Component | GO:0031092 | platelet alpha granule membrane |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005518 | collagen binding |
| Molecular Function | GO:0050840 | extracellular matrix binding |
| Biological Process | GO:0060348 | bone development |
| Biological Process | GO:0071363 | cellular response to growth factor stimulus |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0048839 | inner ear development |
| Biological Process | GO:0030324 | lung development |
| Biological Process | GO:0016525 | negative regulation of angiogenesis |
| Biological Process | GO:0001937 | negative regulation of endothelial cell proliferation |
| Biological Process | GO:0001503 | ossification |
| Biological Process | GO:0043473 | pigmentation |
| Biological Process | GO:0010595 | positive regulation of endothelial cell migration |
| Biological Process | GO:0022604 | regulation of cell morphogenesis |
| Biological Process | GO:0042127 | regulation of cell population proliferation |
| Biological Process | GO:0050807 | regulation of synapse organization |
| Biological Process | GO:0046686 | response to cadmium ion |
| Biological Process | GO:0051592 | response to calcium ion |
| Biological Process | GO:0051591 | response to cAMP |
| Biological Process | GO:0034097 | response to cytokine |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0051384 | response to glucocorticoid |
| Biological Process | GO:0009629 | response to gravity |
| Biological Process | GO:0033591 | response to L-ascorbic acid |
| Biological Process | GO:0010288 | response to lead ion |
| Biological Process | GO:0032496 | response to lipopolysaccharide |
| Biological Process | GO:0043434 | response to peptide hormone |
| Biological Process | GO:0048752 | semicircular canal morphogenesis |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.