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Overview

Uniprot IDP16989
Protein NameY-box-binding protein 3
Gene NameYBX3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
124 FVHQTAIKKNNPRKY
90 EKKVLATKVLGTVKW

Function

Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity)

Protein Sequence

10 MSEAGEATTT 20 TTTTLPQAPT 30 EAAAAAPQDP 40 APKSPVGSGA 50 PQAAAPAPAA 60 HVAGNPGGDA 70 APAATGTAAA 80 ASLATAAGSE 90 DAEKKVLATK 100 VLGTVKWFNV 110 RNGYGFINRN 120 DTKEDVFVHQ 130 TAIKKNNPRK 140 YLRSVGDGET 150 VEFDVVEGEK 160 GAEAANVTGP 170 DGVPVEGSRY 180 AADRRRYRRG 190 YYGRRRGPPR 200 NYAGEEEEEG 210 SGSSEGFDPP 220 ATDRQFSGAR 230 NQLRRPQYRP 240 QYRQRRFPPY 250 HVGQTFDRRS 260 RVLPHPNRIQ 270 AGEIGEMKDG 280 VPEGAQLQGP 290 VHRNPTYRPR 300 YRSRGPPRPR 310 PAPAVGEAED 320 KENQQATSGP 330 NQPSVRRGYR 340 RPYNYRRRPR 350 PPNAPSQDGK 360 EAKAGEAPTE 370 NPAPPTQQSS AE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005923 bicellular tight junction
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0045202 synapse
Molecular Function GO:0003730 mRNA 3'-UTR binding
Molecular Function GO:0003676 nucleic acid binding
Molecular Function GO:0043021 ribonucleoprotein complex binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0070935 3'-UTR-mediated mRNA stabilization
Biological Process GO:0071474 cellular hyperosmotic response
Biological Process GO:0071356 cellular response to tumor necrosis factor
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
Biological Process GO:0060546 negative regulation of necroptotic process
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:2000767 positive regulation of cytoplasmic translation
Biological Process GO:0010468 regulation of gene expression
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.