Search Results
Overview
| Uniprot ID | P17020 |
|---|---|
| Protein Name | Zinc finger protein 16 |
| Gene Name | ZNF16 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 253 | FSQNSVLKNRHRSHM |
Function
Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Also plays a role as an inhibitor of cell apoptosis
Protein Sequence
10
MPSLRTRREE
20
AEMELSVPGP
30
SPWTPAAQAR
40
VRDAPAVTHP
50
GSAACGTPCC
60
SDTELEAICP
70
HYQQPDCDTR
80
TEDKEFLHKE
90
DIHEDLESQA
100
EISENYAGDV
110
SQVPELGDLC
120
DDVSERDWGV
130
PEGRRLPQSL
140
SQEGDFTPAA
150
MGLLRGPLGE
160
KDLDCNGFDS
170
RFSLSPNLMA
180
CQEIPTEERP
190
HPYDMGGQSF
200
QHSVDLTGHE
210
GVPTAESPLI
220
CNECGKTFQG
230
NPDLIQRQIV
240
HTGEASFMCD
250
DCGKTFSQNS
260
VLKNRHRSHM
270
SEKAYQCSEC
280
GKAFRGHSDF
290
SRHQSHHSSE
300
RPYMCNECGK
310
AFSQNSSLKK
320
HQKSHMSEKP
330
YECNECGKAF
340
RRSSNLIQHQ
350
RIHSGEKPYV
360
CSECGKAFRR
370
SSNLIKHHRT
380
HTGEKPFECG
390
ECGKAFSQSA
400
HLRKHQRVHT
410
GEKPYECNDC
420
GKPFSRVSNL
430
IKHHRVHTGE
440
KPYKCSDCGK
450
AFSQSSSLIQ
460
HRRIHTGEKP
470
HVCNVCGKAF
480
SYSSVLRKHQ
490
IIHTGEKPYR
500
CSVCGKAFSH
510
SSALIQHQGV
520
HTGDKPYACH
530
ECGKTFGRSS
540
NLILHQRVHT
550
GEKPYECTEC
560
GKTFSQSSTL
570
IQHQRIHNGL
580
KPHECNQCGK
590
AFNRSSNLIH
600
HQKVHTGEKP
610
YTCVECGKGF
620
SQSSHLIQHQ
630
IIHTGERPYK
640
CSECGKAFSQ
650
RSVLIQHQRI
660
HTGVKPYDCA
670
ACGKAFSQRS
680
KLIKHQLIHT
RE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0072707 | cellular response to sodium dodecyl sulfate |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:1901989 | positive regulation of cell cycle phase transition |
| Biological Process | GO:0051781 | positive regulation of cell division |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0045648 | positive regulation of erythrocyte differentiation |
| Biological Process | GO:0033674 | positive regulation of kinase activity |
| Biological Process | GO:0045654 | positive regulation of megakaryocyte differentiation |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.