Search Results
Overview
| Uniprot ID | P17028 |
|---|---|
| Protein Name | Zinc finger protein 24 |
| Gene Name | ZNF24 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 236 | YGETCFPKGRFERKR |
| 286 | YGCVECGKAFSRSSI |
Function
Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro
Protein Sequence
10
MSAQSVEEDS
20
ILIIPTPDEE
30
EKILRVKLEE
40
DPDGEEGSSI
50
PWNHLPDPEI
60
FRQRFRQFGY
70
QDSPGPREAV
80
SQLRELCRLW
90
LRPETHTKEQ
100
ILELVVLEQF
110
VAILPKELQT
120
WVRDHHPENG
130
EEAVTVLEDL
140
ESELDDPGQP
150
VSLRRRKREV
160
LVEDMVSQEE
170
AQGLPSSELD
180
AVENQLKWAS
190
WELHSLRHCD
200
DDGRTENGAL
210
APKQELPSAL
220
ESHEVPGTLN
230
MGVPQIFKYG
240
ETCFPKGRFE
250
RKRNPSRKKQ
260
HICDECGKHF
270
SQGSALILHQ
280
RIHSGEKPYG
290
CVECGKAFSR
300
SSILVQHQRV
310
HTGEKPYKCL
320
ECGKAFSQNS
330
GLINHQRIHT
340
GEKPYECVQC
350
GKSYSQSSNL
360
FRHQRRHNAE
KLLNVVKV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0043565 | sequence-specific DNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0042552 | myelination |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.