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Overview

Uniprot IDP17078
Protein NameLarge ribosomal subunit protein uL29
Gene NameRpl35
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
13 ARDLRGKKKEELLKQ
35 LSQLRVAKVTGGAAS
43 VTGGAASKLSKIRVV
66 TVINQTQKENLRKFY
77 RKFYKGKKYKPLDLR

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell

Protein Sequence

10 MAKIKARDLR 20 GKKKEELLKQ 30 LDDLKVELSQ 40 LRVAKVTGGA 50 ASKLSKIRVV 60 RKSIARVLTV 70 INQTQKENLR 80 KFYKGKKYKP 90 LDLRPKKTRA 100 MRRRLTKHEE 110 KLKTKKQQRK 120 ERLYPLRKYA VKA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane
Cellular Component GO:0022625 cytosolic large ribosomal subunit
Cellular Component GO:0022626 cytosolic ribosome
Cellular Component GO:0015934 large ribosomal subunit
Cellular Component GO:0045202 synapse
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0043021 ribonucleoprotein complex binding
Molecular Function GO:0003735 structural constituent of ribosome
Biological Process GO:0071493 cellular response to UV-B
Biological Process GO:0002181 cytoplasmic translation
Biological Process GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.