Search Results
Overview
| Uniprot ID | P17105 |
|---|---|
| Protein Name | Inositol-trisphosphate 3-kinase A |
| Gene Name | Itpka |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 167 | GQKSHWQKIRTMVNL |
Function
Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis
Protein Sequence
10
MTLPGHPTGM
20
ARPRGAGPCS
30
PGLERAPRRS
40
VGELRLLFEA
50
RCAAVAAAAA
60
AGEPRARGAK
70
RRGGQVPNGL
80
PRAAPAPVIP
90
QLTVTSEEDV
100
APASPGPPDR
110
EGNWLPAAGS
120
HLQQPRRLST
130
SSLSSTGSSS
140
LLEDSEDDLL
150
SDSESRSRGN
160
VQLETSEDVG
170
QKSHWQKIRT
180
MVNLPVMSPF
190
KKRYSWVQLA
200
GHTGSFKAAG
210
TSGLILKRSS
220
EPEHYCLVRL
230
MADVLRGCVP
240
AFHGVVERDG
250
ESYLQLQDLL
260
DGFDGPCVLD
270
CKMGVRTYLE
280
EELTKARERP
290
KLRKDMYKKM
300
LAVDPEAPTE
310
EEHAQRAVTK
320
PRYMQWREGI
330
SSSTTLGFRI
340
EGIKKADGSC
350
STDFKTTRSR
360
EQVTRVFEEF
370
MQGDAEVLKR
380
YLNRLQQIRD
390
TLEISDFFRR
400
HEVIGSSLLF
410
VHDHCHRAGV
420
WLIDFGKTTP
430
LPDGQILDHR
440
RPWEEGNRED
450
GYLLGLDNLI
GILANLAER
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0098871 | postsynaptic actin cytoskeleton |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004683 | calcium/calmodulin-dependent protein kinase activity |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0000828 | inositol hexakisphosphate kinase activity |
| Molecular Function | GO:0008440 | inositol-1,4,5-trisphosphate 3-kinase activity |
| Molecular Function | GO:0031267 | small GTPase binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0071277 | cellular response to calcium ion |
| Biological Process | GO:0097062 | dendritic spine maintenance |
| Biological Process | GO:0006020 | inositol metabolic process |
| Biological Process | GO:0032958 | inositol phosphate biosynthetic process |
| Biological Process | GO:0098885 | modification of postsynaptic actin cytoskeleton |
| Biological Process | GO:0046854 | phosphatidylinositol phosphate biosynthetic process |
| Biological Process | GO:0061003 | positive regulation of dendritic spine morphogenesis |
| Biological Process | GO:0048167 | regulation of synaptic plasticity |
| Biological Process | GO:0051592 | response to calcium ion |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0098978 | glutamatergic synapse |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.