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Overview

Uniprot IDP17182
Protein NameAlpha-enolase
Gene NameEno1
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
420 IEEELGSKAKFAGRS
60 DKTRFMGKGVSQAVE

Function

Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis. Also involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production

Protein Sequence

10 MSILRIHARE 20 IFDSRGNPTV 30 EVDLYTAKGL 40 FRAAVPSGAS 50 TGIYEALELR 60 DNDKTRFMGK 70 GVSQAVEHIN 80 KTIAPALVSK 90 KVNVVEQEKI 100 DKLMIEMDGT 110 ENKSKFGANA 120 ILGVSLAVCK 130 AGAVEKGVPL 140 YRHIADLAGN 150 PEVILPVPAF 160 NVINGGSHAG 170 NKLAMQEFMI 180 LPVGASSFRE 190 AMRIGAEVYH 200 NLKNVIKEKY 210 GKDATNVGDE 220 GGFAPNILEN 230 KEALELLKTA 240 IAKAGYTDQV 250 VIGMDVAASE 260 FYRSGKYDLD 270 FKSPDDPSRY 280 ITPDQLADLY 290 KSFVQNYPVV 300 SIEDPFDQDD 310 WGAWQKFTAS 320 AGIQVVGDDL 330 TVTNPKRIAK 340 AASEKSCNCL 350 LLKVNQIGSV 360 TESLQACKLA 370 QSNGWGVMVS 380 HRSGETEDTF 390 IADLVVGLCT 400 GQIKTGAPCR 410 SERLAKYNQI 420 LRIEEELGSK 430 AKFAGRSFRN PLAK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0009986 cell surface
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030426 growth cone
Cellular Component GO:0016020 membrane
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0043209 myelin sheath
Cellular Component GO:0005640 nuclear outer membrane
Cellular Component GO:0000015 phosphopyruvate hydratase complex
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0097060 synaptic membrane
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0051020 GTPase binding
Molecular Function GO:0031072 heat shock protein binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0004634 phosphopyruvate hydratase activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function GO:0003714 transcription corepressor activity
Molecular Function GO:0001222 transcription corepressor binding
Biological Process GO:0061621 canonical glycolysis
Biological Process GO:0098761 cellular response to interleukin-7
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0046166 glyceraldehyde-3-phosphate biosynthetic process
Biological Process GO:0006096 glycolytic process
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:2001171 positive regulation of ATP biosynthetic process
Biological Process GO:0045933 positive regulation of muscle contraction
Biological Process GO:0010756 positive regulation of plasminogen activation

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.