Search Results
Overview
| Uniprot ID | P17275 |
|---|---|
| Protein Name | Transcription factor JunB |
| Gene Name | JUNB |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 51 | ADPYRSLKAPGARGP |
Function
Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity)
Protein Sequence
10
MCTKMEQPFY
20
HDDSYTATGY
30
GRAPGGLSLH
40
DYKLLKPSLA
50
VNLADPYRSL
60
KAPGARGPGP
70
EGGGGGSYFS
80
GQGSDTGASL
90
KLASSELERL
100
IVPNSNGVIT
110
TTPTPPGQYF
120
YPRGGGSGGG
130
AGGAGGGVTE
140
EQEGFADGFV
150
KALDDLHKMN
160
HVTPPNVSLG
170
ATGGPPAGPG
180
GVYAGPEPPP
190
VYTNLSSYSP
200
ASASSGGAGA
210
AVGTGSSYPT
220
TTISYLPHAP
230
PFAGGHPAQL
240
GLGRGASTFK
250
EEPQTVPEAR
260
SRDATPPVSP
270
INMEDQERIK
280
VERKRLRNRL
290
AATKCRKRKL
300
ERIARLEDKV
310
KTLKAENAGL
320
SSTAGLLREQ
330
VAQLKQKVMT
340
HVSNGCQLLL
GVKGHAF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0035976 | transcription factor AP-1 complex |
| Cellular Component | GO:0005667 | transcription regulator complex |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0140467 | integrated stress response signaling |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:0042127 | regulation of cell population proliferation |
| Biological Process | GO:2000319 | regulation of T-helper 17 cell differentiation |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0048545 | response to steroid hormone |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.