Search Results
Overview
| Uniprot ID | P17301 |
|---|---|
| Protein Name | Integrin alpha-2 |
| Gene Name | ITGA2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 261 | GAIQYARKYAYSAAS |
Function
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix
Protein Sequence
10
MGPERTGAAP
20
LPLLLVLALS
30
QGILNCCLAY
40
NVGLPEAKIF
50
SGPSSEQFGY
60
AVQQFINPKG
70
NWLLVGSPWS
80
GFPENRMGDV
90
YKCPVDLSTA
100
TCEKLNLQTS
110
TSIPNVTEMK
120
TNMSLGLILT
130
RNMGTGGFLT
140
CGPLWAQQCG
150
NQYYTTGVCS
160
DISPDFQLSA
170
SFSPATQPCP
180
SLIDVVVVCD
190
ESNSIYPWDA
200
VKNFLEKFVQ
210
GLDIGPTKTQ
220
VGLIQYANNP
230
RVVFNLNTYK
240
TKEEMIVATS
250
QTSQYGGDLT
260
NTFGAIQYAR
270
KYAYSAASGG
280
RRSATKVMVV
290
VTDGESHDGS
300
MLKAVIDQCN
310
HDNILRFGIA
320
VLGYLNRNAL
330
DTKNLIKEIK
340
AIASIPTERY
350
FFNVSDEAAL
360
LEKAGTLGEQ
370
IFSIEGTVQG
380
GDNFQMEMSQ
390
VGFSADYSSQ
400
NDILMLGAVG
410
AFGWSGTIVQ
420
KTSHGHLIFP
430
KQAFDQILQD
440
RNHSSYLGYS
450
VAAISTGEST
460
HFVAGAPRAN
470
YTGQIVLYSV
480
NENGNITVIQ
490
AHRGDQIGSY
500
FGSVLCSVDV
510
DKDTITDVLL
520
VGAPMYMSDL
530
KKEEGRVYLF
540
TIKEGILGQH
550
QFLEGPEGIE
560
NTRFGSAIAA
570
LSDINMDGFN
580
DVIVGSPLEN
590
QNSGAVYIYN
600
GHQGTIRTKY
610
SQKILGSDGA
620
FRSHLQYFGR
630
SLDGYGDLNG
640
DSITDVSIGA
650
FGQVVQLWSQ
660
SIADVAIEAS
670
FTPEKITLVN
680
KNAQIILKLC
690
FSAKFRPTKQ
700
NNQVAIVYNI
710
TLDADGFSSR
720
VTSRGLFKEN
730
NERCLQKNMV
740
VNQAQSCPEH
750
IIYIQEPSDV
760
VNSLDLRVDI
770
SLENPGTSPA
780
LEAYSETAKV
790
FSIPFHKDCG
800
EDGLCISDLV
810
LDVRQIPAAQ
820
EQPFIVSNQN
830
KRLTFSVTLK
840
NKRESAYNTG
850
IVVDFSENLF
860
FASFSLPVDG
870
TEVTCQVAAS
880
QKSVACDVGY
890
PALKREQQVT
900
FTINFDFNLQ
910
NLQNQASLSF
920
QALSESQEEN
930
KADNLVNLKI
940
PLLYDAEIHL
950
TRSTNINFYE
960
ISSDGNVPSI
970
VHSFEDVGPK
980
FIFSLKVTTG
990
SVPVSMATVI
1000
IHIPQYTKEK
1010
NPLMYLTGVQ
1020
TDKAGDISCN
1030
ADINPLKIGQ
1040
TSSSVSFKSE
1050
NFRHTKELNC
1060
RTASCSNVTC
1070
WLKDVHMKGE
1080
YFVNVTTRIW
1090
NGTFASSTFQ
1100
TVQLTAAAEI
1110
NTYNPEIYVI
1120
EDNTVTIPLM
1130
IMKPDEKAEV
1140
PTGVIIGSII
1150
AGILLLLALV
1160
AILWKLGFFK
1170
RKYEKMTKNP
1180
DEIDETTELS
S
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0043679 | axon terminus |
| Biological Process | GO:0045785 | positive regulation of cell adhesion |
| Biological Process | GO:0031346 | positive regulation of cell projection organization |
| Biological Process | GO:0032967 | positive regulation of collagen biosynthetic process |
| Biological Process | GO:0010634 | positive regulation of epithelial cell migration |
| Biological Process | GO:0002687 | positive regulation of leukocyte migration |
| Biological Process | GO:0060100 | positive regulation of phagocytosis, engulfment |
| Biological Process | GO:0050927 | positive regulation of positive chemotaxis |
| Biological Process | GO:0014911 | positive regulation of smooth muscle cell migration |
| Biological Process | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| Biological Process | GO:0045987 | positive regulation of smooth muscle contraction |
| Biological Process | GO:0045727 | positive regulation of translation |
| Biological Process | GO:0051971 | positive regulation of transmission of nerve impulse |
| Biological Process | GO:0014075 | response to amine |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0033591 | response to L-ascorbic acid |
| Biological Process | GO:0014850 | response to muscle activity |
| Biological Process | GO:0071107 | response to parathyroid hormone |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0043589 | skin morphogenesis |
| Biological Process | GO:0006929 | substrate-dependent cell migration |
| Cellular Component | GO:0045178 | basal part of cell |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0034666 | integrin alpha2-beta1 complex |
| Cellular Component | GO:0008305 | integrin complex |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Molecular Function | GO:0005518 | collagen binding |
| Molecular Function | GO:0098639 | collagen binding involved in cell-matrix adhesion |
| Molecular Function | GO:0038064 | collagen receptor activity |
| Molecular Function | GO:0043395 | heparan sulfate proteoglycan binding |
| Molecular Function | GO:0005178 | integrin binding |
| Molecular Function | GO:0043236 | laminin binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0038023 | signaling receptor activity |
| Molecular Function | GO:0001618 | virus receptor activity |
| Biological Process | GO:0009887 | animal organ morphogenesis |
| Biological Process | GO:0007596 | blood coagulation |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0033627 | cell adhesion mediated by integrin |
| Biological Process | GO:0098609 | cell-cell adhesion |
| Biological Process | GO:0007160 | cell-matrix adhesion |
| Biological Process | GO:0031589 | cell-substrate adhesion |
| Biological Process | GO:0071392 | cellular response to estradiol stimulus |
| Biological Process | GO:0071260 | cellular response to mechanical stimulus |
| Biological Process | GO:0038065 | collagen-activated signaling pathway |
| Biological Process | GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain |
| Biological Process | GO:0030198 | extracellular matrix organization |
| Biological Process | GO:0007565 | female pregnancy |
| Biological Process | GO:0048041 | focal adhesion assembly |
| Biological Process | GO:0070365 | hepatocyte differentiation |
| Biological Process | GO:0006971 | hypotonic response |
| Biological Process | GO:0007229 | integrin-mediated signaling pathway |
| Biological Process | GO:0030879 | mammary gland development |
| Biological Process | GO:0048333 | mesodermal cell differentiation |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.