Search Results

Overview

Uniprot IDP17302
Protein NameGap junction alpha-1 protein
Gene NameGJA1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
128 VNVDMHLKQIEIKKF
136 QIEIKKFKYGIEEHG
144 YGIEEHGKVKMRGGL
243 VKDRVKGKSDPYHAT

Function

Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells (By similarity). Forms homotypic and heterotypic channels gated by transjunctional voltage (By similarity). May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph (Probable). Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in the conductive system of ventricular myocardium and heart morphogenesis (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization (By similarity). Involved in intercellular innate immune signaling (PubMed:24077100, PubMed:31992625, PubMed:40010341). Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response (PubMed:24077100, PubMed:31992625, PubMed:40010341)

Protein Sequence

10 MGDWSALGKL 20 LDKVQAYSTA 30 GGKVWLSVLF 40 IFRILLLGTA 50 VESAWGDEQS 60 AFRCNTQQPG 70 CENVCYDKSF 80 PISHVRFWVL 90 QIIFVSVPTL 100 LYLAHVFYVM 110 RKEEKLNKKE 120 EELKVAQTDG 130 VNVDMHLKQI 140 EIKKFKYGIE 150 EHGKVKMRGG 160 LLRTYIISIL 170 FKSIFEVAFL 180 LIQWYIYGFS 190 LSAVYTCKRD 200 PCPHQVDCFL 210 SRPTEKTIFI 220 IFMLVVSLVS 230 LALNIIELFY 240 VFFKGVKDRV 250 KGKSDPYHAT 260 SGALSPAKDC 270 GSQKYAYFNG 280 CSSPTAPLSP 290 MSPPGYKLVT 300 GDRNNSSCRN 310 YNKQASEQNW 320 ANYSAEQNRM 330 GQAGSTISNS 340 HAQPFDFPDD 350 NQNSKKLAAG 360 HELQPLAIVD 370 QRPSSRASSR 380 ASSRPRPDDL EI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0030054 cell junction
Cellular Component GO:0044291 cell-cell contact zone
Cellular Component GO:0005922 connexin complex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005921 gap junction
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0030660 Golgi-associated vesicle membrane
Cellular Component GO:0014704 intercalated disc
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0070160 tight junction
Molecular Function GO:0043014 alpha-tubulin binding
Molecular Function GO:0008013 beta-catenin binding
Molecular Function GO:0015562 efflux transmembrane transporter activity
Molecular Function GO:0005243 gap junction channel activity
Molecular Function GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling
Molecular Function GO:1903763 gap junction channel activity involved in cell communication by electrical coupling
Molecular Function GO:0055077 gap junction hemi-channel activity
Molecular Function GO:0034634 glutathione transmembrane transporter activity
Molecular Function GO:0015075 monoatomic ion transmembrane transporter activity
Molecular Function GO:0015631 tubulin binding
Biological Process GO:0086014 atrial cardiac muscle cell action potential
Biological Process GO:0060348 bone development
Biological Process GO:0046849 bone remodeling
Biological Process GO:0003161 cardiac conduction system development
Biological Process GO:0010644 cell communication by electrical coupling
Biological Process GO:0086064 cell communication by electrical coupling involved in cardiac conduction
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:1904646 cellular response to amyloid-beta
Biological Process GO:0000132 establishment of mitotic spindle orientation
Biological Process GO:0140115 export across plasma membrane
Biological Process GO:0016264 gap junction assembly
Biological Process GO:0014047 glutamate secretion
Biological Process GO:0007507 heart development
Biological Process GO:0045087 innate immune response
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:0035633 maintenance of blood-brain barrier
Biological Process GO:0099111 microtubule-based transport
Biological Process GO:0034220 monoatomic ion transmembrane transport
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:0032277 negative regulation of gonadotropin secretion
Biological Process GO:1901164 negative regulation of trophoblast cell migration
Biological Process GO:0043123 positive regulation of canonical NF-kappaB signal transduction
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:1905772 positive regulation of mesodermal cell differentiation
Biological Process GO:1905332 positive regulation of morphogenesis of an epithelium
Biological Process GO:2000648 positive regulation of stem cell proliferation
Biological Process GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
Biological Process GO:0007165 signal transduction
Biological Process GO:0007283 spermatogenesis
Biological Process GO:0042908 xenobiotic transport

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.