Search Results

Overview

Uniprot IDP17480
Protein NameNucleolar transcription factor 1
Gene NameUBTF
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
107 YKGKKLKKHPDFPKK
151 KILSKKYKELPEKKK
212 LWYTHEKKVYLKVRP
216 HEKKVYLKVRPDATT
284 ITKSTLTKAERQLKD
384 EKMLNINKKQATSPA
385 KMLNINKKQATSPAS
393 QATSPASKKPAQEGG
464 KAREAALKAQSERKP
658 NKRKSMTKLRGPNPK
665 KLRGPNPKSSRTTLQ

Function

Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape

Protein Sequence

10 MNGEADCPTD 20 LEMAAPKGQD 30 RWSQEDMLTL 40 LECMKNNLPS 50 NDSSKFKTTE 60 SHMDWEKVAF 70 KDFSGDMCKL 80 KWVEISNEVR 90 KFRTLTELIL 100 DAQEHVKNPY 110 KGKKLKKHPD 120 FPKKPLTPYF 130 RFFMEKRAKY 140 AKLHPEMSNL 150 DLTKILSKKY 160 KELPEKKKMK 170 YIQDFQREKQ 180 EFERNLARFR 190 EDHPDLIQNA 200 KKSDIPEKPK 210 TPQQLWYTHE 220 KKVYLKVRPD 230 ATTKEVKDSL 240 GKQWSQLSDK 250 KRLKWIHKAL 260 EQRKEYEEIM 270 RDYIQKHPEL 280 NISEEGITKS 290 TLTKAERQLK 300 DKFDGRPTKP 310 PPNSYSLYCA 320 ELMANMKDVP 330 STERMVLCSQ 340 QWKLLSQKEK 350 DAYHKKCDQK 360 KKDYEVELLR 370 FLESLPEEEQ 380 QRVLGEEKML 390 NINKKQATSP 400 ASKKPAQEGG 410 KGGSEKPKRP 420 VSAMFIFSEE 430 KRRQLQEERP 440 ELSESELTRL 450 LARMWNDLSE 460 KKKAKYKARE 470 AALKAQSERK 480 PGGEREERGK 490 LPESPKRAEE 500 IWQQSVIGDY 510 LARFKNDRVK 520 ALKAMEMTWN 530 NMEKKEKLMW 540 IKKAAEDQKR 550 YERELSEMRA 560 PPAATNSSKK 570 MKFQGEPKKP 580 PMNGYQKFSQ 590 ELLSNGELNH 600 LPLKERMVEI 610 GSRWQRISQS 620 QKEHYKKLAE 630 EQQKQYKVHL 640 DLWVKSLSPQ 650 DRAAYKEYIS 660 NKRKSMTKLR 670 GPNPKSSRTT 680 LQSKSESEED 690 DEEDEDDEDE 700 DEEEEDDENG 710 DSSEDGGDSS 720 ESSSEDESED 730 GDENEEDDED 740 EDDDEDDDED 750 EDNESEGSSS 760 SSSSSGDSSD SDSN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0001650 fibrillar center
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0001165 RNA polymerase I cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding
Molecular Function GO:0001181 RNA polymerase I general transcription initiation factor activity
Molecular Function GO:0097110 scaffold protein binding
Biological Process GO:0045943 positive regulation of transcription by RNA polymerase I
Biological Process GO:0006360 transcription by RNA polymerase I
Biological Process GO:0006361 transcription initiation at RNA polymerase I promoter

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.