Overview
| Uniprot ID | P17544 |
|---|
| Protein Name | Cyclic AMP-dependent transcription factor ATF-7 |
|---|
| Gene Name | ATF7 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 354 |
SRCRQKRKLWVSSLE |
| 406 |
PVTALQKKTQGYLES |
Function
Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation (PubMed:29490055). In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes (By similarity). Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation (By similarity). In response to TNF, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening (PubMed:29490055). Also plays a role in maintaining epithelial regenerative capacity and protecting against cell death during intestinal epithelial damage and repair (By similarity)
Protein Sequence
10
MGDDRPFVCN
20
APGCGQRFTN
30
EDHLAVHKHK
40
HEMTLKFGPA
50
RTDSVIIADQ
60
TPTPTRFLKN
70
CEEVGLFNEL
80
ASSFEHEFKK
90
AADEDEKKAA
100
AGPLDMSLPS
110
TPDIKIKEEE
120
PVEVDSSPPD
130
SPASSPCSPP
140
LKEKEVTPKP
150
VLISTPTPTI
160
VRPGSLPLHL
170
GYDPLHPTLP
180
SPTSVITQAP
190
PSNRQMGSPT
200
GSLPLVMHLA
210
NGQTMPVLPG
220
PPVQMPSVIS
230
LARPVSMVPN
240
IPGIPGPPVN
250
SSGSISPSGH
260
PIPSEAKMRL
270
KATLTHQVSS
280
INGGCGMVVG
290
TASTMVTARP
300
EQSQILIQHP
310
DAPSPAQPQV
320
SPAQPTPSTG
330
GRRRRTVDED
340
PDERRQRFLE
350
RNRAAASRCR
360
QKRKLWVSSL
370
EKKAEELTSQ
380
NIQLSNEVTL
390
LRNEVAQLKQ
400
LLLAHKDCPV
410
TALQKKTQGY
420
LESPKESSEP
430
TGSPAPVIQH
440
SSATAPSNGL
450
SVRSAAEAVA
460
TSVLTQMASQ
470
RTELSMPIQS
480
HVIMTPQSQS
AGR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0000781 |
chromosome, telomeric region |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0035497 |
cAMP response element binding |
| Molecular Function |
GO:0003700 |
DNA-binding transcription factor activity |
| Molecular Function |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function |
GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function |
GO:0019899 |
enzyme binding |
| Molecular Function |
GO:0051019 |
mitogen-activated protein kinase binding |
| Molecular Function |
GO:0000978 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:1990837 |
sequence-specific double-stranded DNA binding |
| Molecular Function |
GO:0001223 |
transcription coactivator binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.