Search Results
Overview
| Uniprot ID | P17600 |
|---|---|
| Protein Name | Synapsin-1 |
| Gene Name | SYN1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 128 | EPHTDWAKYFKGKKI |
| 134 | AKYFKGKKIHGEIDI |
| 179 | VKVVRSLKPDFVLIR |
| 238 | QMVRLHKKLGTEEFP |
| 311 | AEPFIDAKYDVRVQK |
| 318 | KYDVRVQKIGQNYKA |
| 576 | VSGPAPPKASGAPPG |
| 633 | PGPAGRPKPQLAQKP |
Function
Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity)
Protein Sequence
10
MNYLRRRLSD
20
SNFMANLPNG
30
YMTDLQRPQP
40
PPPPPGAHSP
50
GATPGPGTAT
60
AERSSGVAPA
70
ASPAAPSPGS
80
SGGGGFFSSL
90
SNAVKQTTAA
100
AAATFSEQVG
110
GGSGGAGRGG
120
AASRVLLVID
130
EPHTDWAKYF
140
KGKKIHGEID
150
IKVEQAEFSD
160
LNLVAHANGG
170
FSVDMEVLRN
180
GVKVVRSLKP
190
DFVLIRQHAF
200
SMARNGDYRS
210
LVIGLQYAGI
220
PSVNSLHSVY
230
NFCDKPWVFA
240
QMVRLHKKLG
250
TEEFPLIDQT
260
FYPNHKEMLS
270
STTYPVVVKM
280
GHAHSGMGKV
290
KVDNQHDFQD
300
IASVVALTKT
310
YATAEPFIDA
320
KYDVRVQKIG
330
QNYKAYMRTS
340
VSGNWKTNTG
350
SAMLEQIAMS
360
DRYKLWVDTC
370
SEIFGGLDIC
380
AVEALHGKDG
390
RDHIIEVVGS
400
SMPLIGDHQD
410
EDKQLIVELV
420
VNKMAQALPR
430
QRQRDASPGR
440
GSHGQTPSPG
450
ALPLGRQTSQ
460
QPAGPPAQQR
470
PPPQGGPPQP
480
GPGPQRQGPP
490
LQQRPPPQGQ
500
QHLSGLGPPA
510
GSPLPQRLPS
520
PTSAPQQPAS
530
QAAPPTQGQG
540
RQSRPVAGGP
550
GAPPAARPPA
560
SPSPQRQAGP
570
PQATRQTSVS
580
GPAPPKASGA
590
PPGGQQRQGP
600
PQKPPGPAGP
610
TRQASQAGPV
620
PRTGPPTTQQ
630
PRPSGPGPAG
640
RPKPQLAQKP
650
SQDVPPPATA
660
AAGGPPHPQL
670
NKSQSLTNAF
680
NLPEPAPPRP
690
SLSQDEVKAE
700
TIRSLRKSFA
SLFSD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0048786 | presynaptic active zone |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Cellular Component | GO:0000795 | synaptonemal complex |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0106006 | cytoskeletal protein-membrane anchor activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0048666 | neuron development |
| Biological Process | GO:0007269 | neurotransmitter secretion |
| Biological Process | GO:0046928 | regulation of neurotransmitter secretion |
| Biological Process | GO:0098693 | regulation of synaptic vesicle cycle |
| Biological Process | GO:2000300 | regulation of synaptic vesicle exocytosis |
| Biological Process | GO:0050808 | synapse organization |
| Biological Process | GO:0097091 | synaptic vesicle clustering |
| Cellular Component | GO:0044297 | cell body |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0098850 | extrinsic component of synaptic vesicle membrane |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0098793 | presynapse |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.