Overview
| Uniprot ID | P17661 |
|---|
| Protein Name | Desmin |
|---|
| Gene Name | DES |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 125 |
RFANYIEKVRFLEQQ |
| 299 |
AEEWYKSKVSDLTQA |
Function
Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity)
Protein Sequence
10
MSQAYSSSQR
20
VSSYRRTFGG
30
APGFPLGSPL
40
SSPVFPRAGF
50
GSKGSSSSVT
60
SRVYQVSRTS
70
GGAGGLGSLR
80
ASRLGTTRTP
90
SSYGAGELLD
100
FSLADAVNQE
110
FLTTRTNEKV
120
ELQELNDRFA
130
NYIEKVRFLE
140
QQNAALAAEV
150
NRLKGREPTR
160
VAELYEEELR
170
ELRRQVEVLT
180
NQRARVDVER
190
DNLLDDLQRL
200
KAKLQEEIQL
210
KEEAENNLAA
220
FRADVDAATL
230
ARIDLERRIE
240
SLNEEIAFLK
250
KVHEEEIREL
260
QAQLQEQQVQ
270
VEMDMSKPDL
280
TAALRDIRAQ
290
YETIAAKNIS
300
EAEEWYKSKV
310
SDLTQAANKN
320
NDALRQAKQE
330
MMEYRHQIQS
340
YTCEIDALKG
350
TNDSLMRQMR
360
ELEDRFASEA
370
SGYQDNIARL
380
EEEIRHLKDE
390
MARHLREYQD
400
LLNVKMALDV
410
EIATYRKLLE
420
GEESRINLPI
430
QTYSALNFRE
440
TSPEQRGSEV
450
HTKKTVMIKT
460
IETRDGEVVS
470
EATQQQHEVL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0097512 |
cardiac myofibril |
| Cellular Component |
GO:0031594 |
neuromuscular junction |
| Cellular Component |
GO:0005635 |
nuclear envelope |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0042383 |
sarcolemma |
| Cellular Component |
GO:0030018 |
Z disc |
| Molecular Function |
GO:0008092 |
cytoskeletal protein binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0005200 |
structural constituent of cytoskeleton |
| Biological Process |
GO:0007010 |
cytoskeleton organization |
| Biological Process |
GO:0045109 |
intermediate filament organization |
| Biological Process |
GO:0006936 |
muscle contraction |
| Biological Process |
GO:0006998 |
nuclear envelope organization |
| Biological Process |
GO:0008016 |
regulation of heart contraction |
| Biological Process |
GO:0060538 |
skeletal muscle organ development |
| Cellular Component |
GO:0051286 |
cell tip |
| Cellular Component |
GO:0005911 |
cell-cell junction |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005916 |
fascia adherens |
| Cellular Component |
GO:0014704 |
intercalated disc |
| Cellular Component |
GO:0005882 |
intermediate filament |
| Cellular Component |
GO:0045111 |
intermediate filament cytoskeleton |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.