Search Results
Overview
| Uniprot ID | P17676 |
|---|---|
| Protein Name | CCAAT/enhancer-binding protein beta |
| Gene Name | CEBPB |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 133 | YGGKNCKKPAEYGYV |
| 187 | EPADCKRKEEAGAPG |
| 260 | APAPSQVKSKAKKTV |
| 262 | APSQVKSKAKKTVDK |
Function
Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:12048245, PubMed:1741402, PubMed:18647749, PubMed:9374525). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0036488 | CHOP-C/EBP complex |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045600 | positive regulation of fat cell differentiation |
| Biological Process | GO:0050729 | positive regulation of inflammatory response |
| Biological Process | GO:0032753 | positive regulation of interleukin-4 production |
| Biological Process | GO:2000120 | positive regulation of sodium-dependent phosphate transport |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0045595 | regulation of cell differentiation |
| Biological Process | GO:2001198 | regulation of dendritic cell differentiation |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:1901329 | regulation of odontoblast differentiation |
| Biological Process | GO:0045670 | regulation of osteoclast differentiation |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0034976 | response to endoplasmic reticulum stress |
| Biological Process | GO:0035711 | T-helper 1 cell activation |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0000779 | condensed chromosome, centromeric region |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0031490 | chromatin DNA binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0035035 | histone acetyltransferase binding |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0019900 | kinase binding |
| Molecular Function | GO:0035259 | nuclear glucocorticoid receptor binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding |
| Molecular Function | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Molecular Function | GO:0044389 | ubiquitin-like protein ligase binding |
| Biological Process | GO:0006953 | acute-phase response |
| Biological Process | GO:0050873 | brown fat cell differentiation |
| Biological Process | GO:0071347 | cellular response to interleukin-1 |
| Biological Process | GO:0071222 | cellular response to lipopolysaccharide |
| Biological Process | GO:0042742 | defense response to bacterium |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0002432 | granuloma formation |
| Biological Process | GO:0072574 | hepatocyte proliferation |
| Biological Process | GO:0006955 | immune response |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0140467 | integrated stress response signaling |
| Biological Process | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| Biological Process | GO:0097421 | liver regeneration |
| Biological Process | GO:0007613 | memory |
| Biological Process | GO:0061515 | myeloid cell development |
| Biological Process | GO:0042130 | negative regulation of T cell proliferation |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0001541 | ovarian follicle development |
| Biological Process | GO:0070169 | positive regulation of biomineral tissue development |
| Biological Process | GO:0120162 | positive regulation of cold-induced thermogenesis |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.