Search Results
Overview
| Uniprot ID | P17677 |
|---|---|
| Protein Name | Neuromodulin |
| Gene Name | GAP43 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 37 | KAHKAATKIQASFRG |
Function
This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction
Protein Sequence
10
MLCCMRRTKQ
20
VEKNDDDQKI
30
EQDGIKPEDK
40
AHKAATKIQA
50
SFRGHITRKK
60
LKGEKKDDVQ
70
AAEAEANKKD
80
EAPVADGVEK
90
KGEGTTTAEA
100
APATGSKPDE
110
PGKAGETPSE
120
EKKGEGDAAT
130
EQAAPQAPAS
140
SEEKAGSAET
150
ESATKASTDN
160
SPSSKAEDAP
170
AKEEPKQADV
180
PAAVTAAAAT
190
TPAAEDAAAK
200
ATAQPPTETG
210
ESSQAEENIE
220
AVDETKPKES
230
ARQDEGKEEE
PEADQEHA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0031527 | filopodium membrane |
| Cellular Component | GO:0098982 | GABA-ergic synapse |
| Cellular Component | GO:0032584 | growth cone membrane |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0098793 | presynapse |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0035727 | lysophosphatidic acid binding |
| Molecular Function | GO:1901981 | phosphatidylinositol phosphate binding |
| Molecular Function | GO:0001786 | phosphatidylserine binding |
| Biological Process | GO:0016198 | axon choice point recognition |
| Biological Process | GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0051489 | regulation of filopodium assembly |
| Biological Process | GO:0040008 | regulation of growth |
| Biological Process | GO:0099150 | regulation of postsynaptic specialization assembly |
| Biological Process | GO:0010996 | response to auditory stimulus |
| Biological Process | GO:0009611 | response to wounding |
| Biological Process | GO:0042246 | tissue regeneration |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.