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Overview

Uniprot IDP17710
Protein NameHexokinase-1
Gene NameHk1
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
833 GQISEPLKTRGIFET
884 TVCGVVSKRAAQLCG

Function

Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan. When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331)

Protein Sequence

10 MGWGAPLLSR 20 MLHGPGQAGE 30 TSPVPERQSG 40 SENPASEDRR 50 PLEKQCSHHL 60 YTMGQNCQRG 70 QAVDVEPKIR 80 PPLTEEKIDK 90 YLYAMRLSDE 100 ILIDILTRFK 110 KEMKNGLSRD 120 YNPTASVKML 130 PTFVRSIPDG 140 SEKGDFIALD 150 LGGSSFRILR 160 VQVNHEKSQN 170 VSMESEVYDT 180 PENIVHGSGS 190 QLFDHVAECL 200 GDFMEKRKIK 210 DKKLPVGFTF 220 SFPCRQSKID 230 EAVLITWTKR 240 FKASGVEGAD 250 VVKLLNKAIK 260 KRGDYDANIV 270 AVVNDTVGTM 280 MTCGYDDQQC 290 EVGLIIGTGT 300 NACYMEELRH 310 IDLVEGDEGR 320 MCINTEWGAF 330 GDDGSLEDIR 340 TEFDRELDRG 350 SLNPGKQLFE 360 KMVSGMYMGE 370 LVRLILVKMA 380 KESLLFEGRI 390 TPELLTRGKF 400 TTSDVAAIET 410 DKEGVQNAKE 420 ILTRLGVEPS 430 HDDCVSVQHV 440 CTIVSFRSAN 450 LVAATLGAIL 460 NRLRDNKGTP 470 RLRTTVGVDG 480 SLYKMHPQYS 490 RRFHKTLRRL 500 VPDSDVRFLL 510 SESGSGKGAA 520 MVTAVAYRLA 530 EQHRQIEETL 540 SHFRLSKQAL 550 MEVKKKLRSE 560 MEMGLRKETN 570 SRATVKMLPS 580 YVRSIPDGTE 590 HGDFLALDLG 600 GTNFRVLLVK 610 IRSGKKRTVE 620 MHNKIYSIPL 630 EIMQGTGDEL 640 FDHIVSCISD 650 FLDYMGIKGP 660 RMPLGFTFSF 670 PCKQTSLDCG 680 ILITWTKGFK 690 ATDCVGHDVA 700 TLLRDAVKRR 710 EEFDLDVVAV 720 VNDTVGTMMT 730 CAYEEPSCEI 740 GLIVGTGSNA 750 CYMEEMKNVE 760 MVEGNQGQMC 770 INMEWGAFGD 780 NGCLDDIRTD 790 FDKVVDEYSL 800 NSGKQRFEKM 810 ISGMYLGEIV 820 RNILIDFTKK 830 GFLFRGQISE 840 PLKTRGIFET 850 KFLSQIESDR 860 LALLQVRAIL 870 QQLGLNSTCD 880 DSILVKTVCG 890 VVSKRAAQLC 900 GAGMAAVVEK 910 IRENRGLDHL 920 NVTVGVDGTL 930 YKLHPHFSRI 940 MHQTVKELSP 950 KCTVSFLLSE 960 DGSGKGAALI 970 TAVGVRLRGD PTNA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005901 caveola
Cellular Component GO:0005929 cilium
Cellular Component GO:0005829 cytosol
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0097228 sperm principal piece
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005536 D-glucose binding
Molecular Function GO:0008865 fructokinase activity
Molecular Function GO:0004340 glucokinase activity
Molecular Function GO:0047931 glucosamine kinase activity
Molecular Function GO:0004396 hexokinase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019158 mannokinase activity
Molecular Function GO:0042834 peptidoglycan binding
Molecular Function GO:0004672 protein kinase activity
Molecular Function GO:0044877 protein-containing complex binding
Biological Process GO:0061621 canonical glycolysis
Biological Process GO:0046835 carbohydrate phosphorylation
Biological Process GO:0072655 establishment of protein localization to mitochondrion
Biological Process GO:0006002 fructose 6-phosphate metabolic process
Biological Process GO:0051156 glucose 6-phosphate metabolic process
Biological Process GO:0006006 glucose metabolic process
Biological Process GO:0006096 glycolytic process
Biological Process GO:0006954 inflammatory response
Biological Process GO:0045087 innate immune response
Biological Process GO:0001678 intracellular glucose homeostasis
Biological Process GO:0072656 maintenance of protein location in mitochondrion
Biological Process GO:0006013 mannose metabolic process
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0018107 peptidyl-threonine phosphorylation
Biological Process GO:0018108 peptidyl-tyrosine phosphorylation
Biological Process GO:0002720 positive regulation of cytokine production involved in immune response
Biological Process GO:0032731 positive regulation of interleukin-1 beta production
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0002931 response to ischemia

Reference

[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.