Search Results
Overview
| Uniprot ID | P17742 |
|---|---|
| Protein Name | Peptidyl-prolyl cis-trans isomerase A |
| Gene Name | Ppia |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 28 | SFELFADKVPKTAEN |
| 44 | RALSTGEKGFGYKGS |
Function
Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:24429998). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (PubMed:25678563). Plays an important role in platelet activation and aggregation (PubMed:24429998). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (PubMed:24429998). Binds heparan sulfate glycosaminoglycans (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0043209 | myelin sheath |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0016018 | cyclosporin A binding |
| Molecular Function | GO:1904399 | heparan sulfate binding |
| Molecular Function | GO:0005178 | integrin binding |
| Molecular Function | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| Biological Process | GO:0032148 | activation of protein kinase B activity |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0060352 | cell adhesion molecule production |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Biological Process | GO:0034378 | chylomicron assembly |
| Biological Process | GO:0042118 | endothelial cell activation |
| Biological Process | GO:0030595 | leukocyte chemotaxis |
| Biological Process | GO:0034389 | lipid droplet organization |
| Biological Process | GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| Biological Process | GO:0061944 | negative regulation of protein K48-linked ubiquitination |
| Biological Process | GO:0006469 | negative regulation of protein kinase activity |
| Biological Process | GO:0001933 | negative regulation of protein phosphorylation |
| Biological Process | GO:0032873 | negative regulation of stress-activated MAPK cascade |
| Biological Process | GO:1903901 | negative regulation of viral life cycle |
| Biological Process | GO:0030182 | neuron differentiation |
| Biological Process | GO:0030593 | neutrophil chemotaxis |
| Biological Process | GO:0030168 | platelet activation |
| Biological Process | GO:0070527 | platelet aggregation |
| Biological Process | GO:0043410 | positive regulation of MAPK cascade |
| Biological Process | GO:0001934 | positive regulation of protein phosphorylation |
| Biological Process | GO:0050714 | positive regulation of protein secretion |
| Biological Process | GO:0045070 | positive regulation of viral genome replication |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0000413 | protein peptidyl-prolyl isomerization |
| Biological Process | GO:2001233 | regulation of apoptotic signaling pathway |
| Biological Process | GO:0045069 | regulation of viral genome replication |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.