Search Results
Overview
| Uniprot ID | P17751 |
|---|---|
| Protein Name | Triosephosphate isomerase |
| Gene Name | Tpi1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 14 | FFVGGNWKMNGRKKC |
| 142 | REAGITEKVVFEQTK |
| 149 | KVVFEQTKVIADNVK |
| 156 | KVIADNVKDWSKVVL |
| 188 | QAQEVHEKLRGWLKS |
| 194 | EKLRGWLKSNVNDGV |
| 59 | ARQKLDPKIAVAAQN |
Function
Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis
Protein Sequence
10
MAPTRKFFVG
20
GNWKMNGRKK
30
CLGELICTLN
40
AANVPAGTEV
50
VCAPPTAYID
60
FARQKLDPKI
70
AVAAQNCYKV
80
TNGAFTGEIS
90
PGMIKDLGAT
100
WVVLGHSERR
110
HVFGESDELI
120
GQKVSHALAE
130
GLGVIACIGE
140
KLDEREAGIT
150
EKVVFEQTKV
160
IADNVKDWSK
170
VVLAYEPVWA
180
IGTGKTATPQ
190
QAQEVHEKLR
200
GWLKSNVNDG
210
VAQSTRIIYG
220
GSVTGATCKE
230
LASQPDVDGF
240
LVGGASLKPE
FVDIINAKQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0016853 | isomerase activity |
| Molecular Function | GO:0008929 | methylglyoxal synthase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0004807 | triose-phosphate isomerase activity |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0061621 | canonical glycolysis |
| Biological Process | GO:0006094 | gluconeogenesis |
| Biological Process | GO:0006006 | glucose metabolic process |
| Biological Process | GO:0046166 | glyceraldehyde-3-phosphate biosynthetic process |
| Biological Process | GO:0019682 | glyceraldehyde-3-phosphate metabolic process |
| Biological Process | GO:0019563 | glycerol catabolic process |
| Biological Process | GO:0006096 | glycolytic process |
| Biological Process | GO:0019242 | methylglyoxal biosynthetic process |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.