Search Results
Overview
| Uniprot ID | P17931 |
|---|---|
| Protein Name | Galectin-3 |
| Gene Name | LGALS3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 139 | ITILGTVKPNANRIA |
| 176 | RVIVCNTKLDNNWGR |
| 227 | QYNHRVKKLNEISKL |
Function
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes
Protein Sequence
10
MADNFSLHDA
20
LSGSGNPNPQ
30
GWPGAWGNQP
40
AGAGGYPGAS
50
YPGAYPGQAP
60
PGAYPGQAPP
70
GAYPGAPGAY
80
PGAPAPGVYP
90
GPPSGPGAYP
100
SSGQPSATGA
110
YPATGPYGAP
120
AGPLIVPYNL
130
PLPGGVVPRM
140
LITILGTVKP
150
NANRIALDFQ
160
RGNDVAFHFN
170
PRFNENNRRV
180
IVCNTKLDNN
190
WGREERQSVF
200
PFESGKPFKI
210
QVLVEPDHFK
220
VAVNDAHLLQ
230
YNHRVKKLNE
240
ISKLGISGDI
250
DLTSASYTMI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0101003 | ficolin-1-rich granule membrane |
| Cellular Component | GO:0001772 | immunological synapse |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0030667 | secretory granule membrane |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Molecular Function | GO:0030246 | carbohydrate binding |
| Molecular Function | GO:0042056 | chemoattractant activity |
| Molecular Function | GO:0048030 | disaccharide binding |
| Molecular Function | GO:0019863 | IgE binding |
| Molecular Function | GO:0043236 | laminin binding |
| Molecular Function | GO:0140693 | molecular condensate scaffold activity |
| Molecular Function | GO:0019903 | protein phosphatase binding |
| Molecular Function | GO:0004864 | protein phosphatase inhibitor activity |
| Molecular Function | GO:0141069 | receptor ligand inhibitor activity |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0048245 | eosinophil chemotaxis |
| Biological Process | GO:0030855 | epithelial cell differentiation |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0048246 | macrophage chemotaxis |
| Biological Process | GO:0002548 | monocyte chemotaxis |
| Biological Process | GO:0071674 | mononuclear cell migration |
| Biological Process | GO:0006397 | mRNA processing |
| Biological Process | GO:0045806 | negative regulation of endocytosis |
| Biological Process | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| Biological Process | GO:2000521 | negative regulation of immunological synapse formation |
| Biological Process | GO:0051134 | negative regulation of NK T cell activation |
| Biological Process | GO:2001189 | negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
| Biological Process | GO:0050860 | negative regulation of T cell receptor signaling pathway |
| Biological Process | GO:0030593 | neutrophil chemotaxis |
| Biological Process | GO:0050918 | positive chemotaxis |
| Biological Process | GO:0090280 | positive regulation of calcium ion import |
| Biological Process | GO:0071677 | positive regulation of mononuclear cell migration |
| Biological Process | GO:1903078 | positive regulation of protein localization to plasma membrane |
| Biological Process | GO:0031334 | positive regulation of protein-containing complex assembly |
| Biological Process | GO:1902041 | regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| Biological Process | GO:0070232 | regulation of T cell apoptotic process |
| Biological Process | GO:0042129 | regulation of T cell proliferation |
| Biological Process | GO:0008380 | RNA splicing |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.