Search Results

Overview

Uniprot IDP17980
Protein Name26S proteasome regulatory subunit 6A
Gene NamePSMC3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
245 RACAAQTKATFLKLA
276 RDAFALAKEKAPSII
278 AFALAKEKAPSIIFI
56 DSEIKIMKSEVLRVT
70 THELQAMKDKIKENS

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides

Protein Sequence

10 MNLLPNIESP 20 VTRQEKMATV 30 WDEAEQDGIG 40 EEVLKMSTEE 50 IIQRTRLLDS 60 EIKIMKSEVL 70 RVTHELQAMK 80 DKIKENSEKI 90 KVNKTLPYLV 100 SNVIELLDVD 110 PNDQEEDGAN 120 IDLDSQRKGK 130 CAVIKTSTRQ 140 TYFLPVIGLV 150 DAEKLKPGDL 160 VGVNKDSYLI 170 LETLPTEYDS 180 RVKAMEVDER 190 PTEQYSDIGG 200 LDKQIQELVE 210 AIVLPMNHKE 220 KFENLGIQPP 230 KGVLMYGPPG 240 TGKTLLARAC 250 AAQTKATFLK 260 LAGPQLVQMF 270 IGDGAKLVRD 280 AFALAKEKAP 290 SIIFIDELDA 300 IGTKRFDSEK 310 AGDREVQRTM 320 LELLNQLDGF 330 QPNTQVKVIA 340 ATNRVDILDP 350 ALLRSGRLDR 360 KIEFPMPNEE 370 ARARIMQIHS 380 RKMNVSPDVN 390 YEELARCTDD 400 FNGAQCKAVC 410 VEAGMIALRR 420 GATELTHEDY 430 MEGILEVQAK KKANLQYYA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000932 P-body
Cellular Component GO:0022624 proteasome accessory complex
Cellular Component GO:0000502 proteasome complex
Cellular Component GO:0008540 proteasome regulatory particle, base subcomplex
Cellular Component GO:0034774 secretory granule lumen
Cellular Component GO:0008021 synaptic vesicle
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0036402 proteasome-activating activity
Biological Process GO:0071357 cellular response to type I interferon
Biological Process GO:0043921 host-mediated perturbation of viral transcription
Biological Process GO:1901800 positive regulation of proteasomal protein catabolic process
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0010498 proteasomal protein catabolic process
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0061136 regulation of proteasomal protein catabolic process
Biological Process GO:0006979 response to oxidative stress

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.