Search Results
Overview
| Uniprot ID | P18031 |
|---|---|
| Protein Name | Tyrosine-protein phosphatase non-receptor type 1 |
| Gene Name | PTPN1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 120 | VMEKGSLKCAQYWPQ |
| 323 | ILEPHNGKCREFFPN |
| 58 | PFDHSRIKLHQEDND |
Function
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET
Protein Sequence
10
MEMEKEFEQI
20
DKSGSWAAIY
30
QDIRHEASDF
40
PCRVAKLPKN
50
KNRNRYRDVS
60
PFDHSRIKLH
70
QEDNDYINAS
80
LIKMEEAQRS
90
YILTQGPLPN
100
TCGHFWEMVW
110
EQKSRGVVML
120
NRVMEKGSLK
130
CAQYWPQKEE
140
KEMIFEDTNL
150
KLTLISEDIK
160
SYYTVRQLEL
170
ENLTTQETRE
180
ILHFHYTTWP
190
DFGVPESPAS
200
FLNFLFKVRE
210
SGSLSPEHGP
220
VVVHCSAGIG
230
RSGTFCLADT
240
CLLLMDKRKD
250
PSSVDIKKVL
260
LEMRKFRMGL
270
IQTADQLRFS
280
YLAVIEGAKF
290
IMGDSSVQDQ
300
WKELSHEDLE
310
PPPEHIPPPP
320
RPPKRILEPH
330
NGKCREFFPN
340
HQWVKEETQE
350
DKDCPIKEEK
360
GSPLNAAPYG
370
IESMSQDTEV
380
RSRVVGGSLR
390
GAQAASPAKG
400
EPSLPEKDED
410
HALSYWKPFL
420
VNMCVATVLT
430
AGAYLCYRFL
FNSNT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0031904 | endosome lumen |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0030061 | mitochondrial crista |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0097443 | sorting endosome |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0046875 | ephrin receptor binding |
| Molecular Function | GO:0005158 | insulin receptor binding |
| Molecular Function | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity |
| Molecular Function | GO:0004721 | phosphoprotein phosphatase activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0051721 | protein phosphatase 2A binding |
| Molecular Function | GO:0004725 | protein tyrosine phosphatase activity |
| Molecular Function | GO:0030971 | receptor tyrosine kinase binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:1904385 | cellular response to angiotensin |
| Biological Process | GO:0044344 | cellular response to fibroblast growth factor stimulus |
| Biological Process | GO:0071456 | cellular response to hypoxia |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:1990090 | cellular response to nerve growth factor stimulus |
| Biological Process | GO:0071732 | cellular response to nitric oxide |
| Biological Process | GO:0036120 | cellular response to platelet-derived growth factor stimulus |
| Biological Process | GO:0034620 | cellular response to unfolded protein |
| Biological Process | GO:0030968 | endoplasmic reticulum unfolded protein response |
| Biological Process | GO:0060397 | growth hormone receptor signaling pathway via JAK-STAT |
| Biological Process | GO:0038020 | insulin receptor recycling |
| Biological Process | GO:0036498 | IRE1-mediated unfolded protein response |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0010812 | negative regulation of cell-substrate adhesion |
| Biological Process | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| Biological Process | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| Biological Process | GO:0043407 | negative regulation of MAP kinase activity |
| Biological Process | GO:0010977 | negative regulation of neuron projection development |
| Biological Process | GO:1903898 | negative regulation of PERK-mediated unfolded protein response |
| Biological Process | GO:0051898 | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:0009968 | negative regulation of signal transduction |
| Biological Process | GO:1904753 | negative regulation of vascular associated smooth muscle cell migration |
| Biological Process | GO:0030948 | negative regulation of vascular endothelial growth factor receptor signaling pathway |
| Biological Process | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| Biological Process | GO:0035791 | platelet-derived growth factor receptor-beta signaling pathway |
| Biological Process | GO:0010666 | positive regulation of cardiac muscle cell apoptotic process |
| Biological Process | GO:2000353 | positive regulation of endothelial cell apoptotic process |
| Biological Process | GO:0010460 | positive regulation of heart rate |
| Biological Process | GO:1903896 | positive regulation of IRE1-mediated unfolded protein response |
| Biological Process | GO:0046330 | positive regulation of JNK cascade |
| Biological Process | GO:2000646 | positive regulation of receptor catabolic process |
| Biological Process | GO:0003084 | positive regulation of systemic arterial blood pressure |
| Biological Process | GO:0030100 | regulation of endocytosis |
| Biological Process | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway |
| Biological Process | GO:0033157 | regulation of intracellular protein transport |
| Biological Process | GO:0150052 | regulation of postsynapse assembly |
| Biological Process | GO:0030162 | regulation of proteolysis |
| Biological Process | GO:0009966 | regulation of signal transduction |
| Biological Process | GO:0060338 | regulation of type I interferon-mediated signaling pathway |
| Biological Process | GO:0031667 | response to nutrient levels |
| Biological Process | GO:0097706 | vascular endothelial cell response to oscillatory fluid shear stress |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.