Search Results

Overview

Uniprot IDP18206
Protein NameVinculin
Gene NameVCL
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1020 RALIQCAKDIAKASD
1024 QCAKDIAKASDEVTR
1070 LKILSTVKATMLGRT
216 MKIFVTTKNSKNQGI
219 FVTTKNSKNQGIEEA
276 ALASIDSKLNQAKGW
281 DSKLNQAKGWLRDPS
316 VGELCAGKERREILG
381 LEAMTNSKQSIAKKI
417 GALAEARKIAELCDD
426 AELCDDPKERDDILR
488 VANSRPAKAAVHLEG
496 AAVHLEGKIEQAQRW
639 NFENHSGKLGATAEK
646 KLGATAEKAAAVGTA
666 EGIQASVKTARELTP
731 DASEEAIKKDLDKCK
732 ASEEAIKKDLDKCKV
768 NRILLVAKREVENSE
778 VENSEDPKFREAVKA
784 PKFREAVKAASDELS
983 EATKWSSKGNDIIAA
992 NDIIAAAKRMALLMA

Function

Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion

Protein Sequence

10 MPVFHTRTIE 20 SILEPVAQQI 30 SHLVIMHEEG 40 EVDGKAIPDL 50 TAPVAAVQAA 60 VSNLVRVGKE 70 TVQTTEDQIL 80 KRDMPPAFIK 90 VENACTKLVQ 100 AAQMLQSDPY 110 SVPARDYLID 120 GSRGILSGTS 130 DLLLTFDEAE 140 VRKIIRVCKG 150 ILEYLTVAEV 160 VETMEDLVTY 170 TKNLGPGMTK 180 MAKMIDERQQ 190 ELTHQEHRVM 200 LVNSMNTVKE 210 LLPVLISAMK 220 IFVTTKNSKN 230 QGIEEALKNR 240 NFTVEKMSAE 250 INEIIRVLQL 260 TSWDEDAWAS 270 KDTEAMKRAL 280 ASIDSKLNQA 290 KGWLRDPSAS 300 PGDAGEQAIR 310 QILDEAGKVG 320 ELCAGKERRE 330 ILGTCKMLGQ 340 MTDQVADLRA 350 RGQGSSPVAM 360 QKAQQVSQGL 370 DVLTAKVENA 380 ARKLEAMTNS 390 KQSIAKKIDA 400 AQNWLADPNG 410 GPEGEEQIRG 420 ALAEARKIAE 430 LCDDPKERDD 440 ILRSLGEISA 450 LTSKLADLRR 460 QGKGDSPEAR 470 ALAKQVATAL 480 QNLQTKTNRA 490 VANSRPAKAA 500 VHLEGKIEQA 510 QRWIDNPTVD 520 DRGVGQAAIR 530 GLVAEGHRLA 540 NVMMGPYRQD 550 LLAKCDRVDQ 560 LTAQLADLAA 570 RGEGESPQAR 580 ALASQLQDSL 590 KDLKARMQEA 600 MTQEVSDVFS 610 DTTTPIKLLA 620 VAATAPPDAP 630 NREEVFDERA 640 ANFENHSGKL 650 GATAEKAAAV 660 GTANKSTVEG 670 IQASVKTARE 680 LTPQVVSAAR 690 ILLRNPGNQA 700 AYEHFETMKN 710 QWIDNVEKMT 720 GLVDEAIDTK 730 SLLDASEEAI 740 KKDLDKCKVA 750 MANIQPQMLV 760 AGATSIARRA 770 NRILLVAKRE 780 VENSEDPKFR 790 EAVKAASDEL 800 SKTISPMVMD 810 AKAVAGNISD 820 PGLQKSFLDS 830 GYRILGAVAK 840 VREAFQPQEP 850 DFPPPPPDLE 860 QLRLTDELAP 870 PKPPLPEGEV 880 PPPRPPPPEE 890 KDEEFPEQKA 900 GEVINQPMMM 910 AARQLHDEAR 920 KWSSKPGIPA 930 AEVGIGVVAE 940 ADAADAAGFP 950 VPPDMEDDYE 960 PELLLMPSNQ 970 PVNQPILAAA 980 QSLHREATKW 990 SSKGNDIIAA 1000 AKRMALLMAE 1010 MSRLVRGGSG 1020 TKRALIQCAK 1030 DIAKASDEVT 1040 RLAKEVAKQC 1050 TDKRIRTNLL 1060 QVCERIPTIS 1070 TQLKILSTVK 1080 ATMLGRTNIS 1090 DEESEQATEM 1100 LVHNAQNLMQ 1110 SVKETVREAE 1120 AASIKIRTDA 1130 GFTLRWVRKT PWYQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0005903 brush border
Cellular Component GO:0044291 cell-cell contact zone
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0030055 cell-substrate junction
Cellular Component GO:0043034 costamere
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1903561 extracellular vesicle
Cellular Component GO:0005916 fascia adherens
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0090637 inner dense plaque of desmosome
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0090636 outer dense plaque of desmosome
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0061826 podosome ring
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:0034774 secretory granule lumen
Cellular Component GO:0035580 specific granule lumen
Cellular Component GO:1990357 terminal web
Cellular Component GO:0005915 zonula adherens
Molecular Function GO:0003779 actin binding
Molecular Function GO:0045294 alpha-catenin binding
Molecular Function GO:0008013 beta-catenin binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0002162 dystroglycan binding
Molecular Function GO:0060090 molecular adaptor activity
Molecular Function GO:0005198 structural molecule activity
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0034333 adherens junction assembly
Biological Process GO:0043297 apical junction assembly
Biological Process GO:0007155 cell adhesion
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0090136 epithelial cell-cell adhesion
Biological Process GO:0030032 lamellipodium assembly
Biological Process GO:0035633 maintenance of blood-brain barrier
Biological Process GO:0002009 morphogenesis of an epithelium
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:0070527 platelet aggregation
Biological Process GO:0034394 protein localization to cell surface
Biological Process GO:1903140 regulation of establishment of endothelial barrier
Biological Process GO:0051893 regulation of focal adhesion assembly
Biological Process GO:1904702 regulation of protein localization to adherens junction

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.