Search Results
Overview
| Uniprot ID | P18283 |
|---|---|
| Protein Name | Glutathione peroxidase 2 |
| Gene Name | GPX2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 122 | VFAYLKDKLPYPYDD |
Function
Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis (PubMed:36608588, PubMed:8428933). Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides (PubMed:36608588, PubMed:8428933). Cannot reduce phosphatidycholine hydroperoxide (PubMed:8428933)
Protein Sequence
10
MAFIAKSFYD
20
LSAISLDGEK
30
VDFNTFRGRA
40
VLIENVASLU
50
GTTTRDFTQL
60
NELQCRFPRR
70
LVVLGFPCNQ
80
FGHQENCQNE
90
EILNSLKYVR
100
PGGGYQPTFT
110
LVQKCEVNGQ
120
NEHPVFAYLK
130
DKLPYPYDDP
140
FSLMTDPKLI
150
IWSPVRRSDV
160
AWNFEKFLIG
170
PEGEPFRRYS
180
RTFPTINIEP
190
DIKRLLKVAI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0004602 | glutathione peroxidase activity |
| Molecular Function | GO:0047066 | phospholipid-hydroperoxide glutathione peroxidase activity |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0009055 | electron transfer activity |
Reference
PMID: N/A