Search Results
Overview
| Uniprot ID | P18395 |
|---|---|
| Protein Name | Cold shock domain-containing protein E1 |
| Gene Name | Csde1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 277 | VIPKVPSKNQNDPLP |
| 758 | DRLVNRLKNITLDDA |
Function
RNA-binding protein involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Required for efficient formation of stress granules
Protein Sequence
10
MSFDPNLLHN
20
NGHNGYPNGT
30
SAALRETGVI
40
EKLLTSYGFI
50
QCSERQARLF
60
FHCSQYNGNL
70
QDLKVGDDVE
80
FEVSSDRRTG
90
KPIAIKLVKI
100
KPEIHPEERM
110
NGQVVCAVPH
120
NLESKSPAAP
130
GQSPTGSVCY
140
ERNGEVFYLT
150
YTSEDVEGNV
160
QLETGDKINF
170
VIDNNKHTGA
180
VSARNIMLLK
190
KKQARYQGVV
200
CAMKEAFGFI
210
ERGDVVKEIF
220
FHYSEFKGDL
230
ETLQPGDDVE
240
FTIKDRNGKE
250
VATDVRLLPQ
260
GTVIFEDISI
270
EHFEGTVTKV
280
IPKVPSKNQN
290
DPLPGRIKVD
300
FVIPKELPFG
310
DKDTKSKVTL
320
LEGDHVRFNI
330
STDRRDKLER
340
ATNIEVLSNT
350
FQFTNEAREM
360
GVIAAMRDGF
370
GFIKCVDRDA
380
RMFFHFSEIL
390
DGNQLHIADE
400
VEFTVVPDML
410
SAQRNHAIRI
420
KKLPKGTVSF
430
HSHSDHRFLG
440
TVEKEATFSN
450
PKTTSPNKGK
460
DKEAEDGIIA
470
YDDCGVKLTI
480
AFQAKDVEGS
490
TSPQIGDKVE
500
FSISDKQRPG
510
QQIATCVRLL
520
GRNSNSKRLL
530
GYVATLKDNF
540
GFIETANHDK
550
EIFFHYSEFS
560
GDVDSLELGD
570
MVEYSLSKGK
580
GNKVSAEKVN
590
KTHSVNGITE
600
EANPTIYSGK
610
VIRPLRGVDP
620
TQIEYQGMIE
630
IVEEGDMKGE
640
VYPFGIVGMA
650
NKGDCLQKGE
660
SVKFQLCVLG
670
QNAQTMAYNI
680
TPLRRATVEC
690
VKDQFGFINY
700
EVGDSKKLFF
710
HVKEVQDGIE
720
LQAGDEVEFS
730
VILNQRTGKC
740
SACNVWRVCE
750
GPKAVAAPRP
760
DRLVNRLKNI
770
TLDDASAPRL
780
MVLRQPRGPD
790
NSMGFGAERK
IRQAGVID
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0070937 | CRD-mediated mRNA stability complex |
| Cellular Component | GO:0010494 | cytoplasmic stress granule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0106002 | mCRD-mediated mRNA stability complex |
| Cellular Component | GO:0000932 | P-body |
| Molecular Function | GO:0106222 | lncRNA binding |
| Molecular Function | GO:0140517 | protein-RNA adaptor activity |
| Molecular Function | GO:1905172 | RISC complex binding |
| Molecular Function | GO:0035613 | RNA stem-loop binding |
| Biological Process | GO:0070934 | CRD-mediated mRNA stabilization |
| Biological Process | GO:0075522 | IRES-dependent viral translational initiation |
| Biological Process | GO:1900152 | negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| Biological Process | GO:0070966 | nuclear-transcribed mRNA catabolic process, no-go decay |
| Biological Process | GO:2000767 | positive regulation of cytoplasmic translation |
| Biological Process | GO:0045727 | positive regulation of translation |
| Biological Process | GO:0034063 | stress granule assembly |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.