Search Results
Overview
| Uniprot ID | P18418 |
|---|---|
| Protein Name | Calreticulin |
| Gene Name | Calr |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 143 | ICGPGTKKVHVIFNY |
| 151 | VHVIFNYKGKNVLIN |
| 153 | VIFNYKGKNVLINKD |
| 159 | GKNVLINKDIRCKDD |
| 209 | FLPPKKIKDPDAAKP |
| 360 | AEKQMKDKQDEEQRL |
| 374 | LKEEEEDKKRKEEEE |
| 375 | KEEEEDKKRKEEEEA |
| 41 | TNRWVESKHKSDFGK |
| 43 | RWVESKHKSDFGKFV |
| 48 | KHKSDFGKFVLSSGK |
| 55 | KFVLSSGKFYGDQEK |
| 62 | KFYGDQEKDKGLQTS |
| 64 | YGDQEKDKGLQTSQD |
Function
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity)
Protein Sequence
10
MLLSVPLLLG
20
LLGLAAADPA
30
IYFKEQFLDG
40
DAWTNRWVES
50
KHKSDFGKFV
60
LSSGKFYGDQ
70
EKDKGLQTSQ
80
DARFYALSAR
90
FEPFSNKGQT
100
LVVQFTVKHE
110
QNIDCGGGYV
120
KLFPGGLDQK
130
DMHGDSEYNI
140
MFGPDICGPG
150
TKKVHVIFNY
160
KGKNVLINKD
170
IRCKDDEFTH
180
LYTLIVRPDN
190
TYEVKIDNSQ
200
VESGSLEDDW
210
DFLPPKKIKD
220
PDAAKPEDWD
230
ERAKIDDPTD
240
SKPEDWDKPE
250
HIPDPDAKKP
260
EDWDEEMDGE
270
WEPPVIQNPE
280
YKGEWKPRQI
290
DNPDYKGTWI
300
HPEIDNPEYS
310
PDANIYAYDS
320
FAVLGLDLWQ
330
VKSGTIFDNF
340
LITNDEAYAE
350
EFGNETWGVT
360
KAAEKQMKDK
370
QDEEQRLKEE
380
EEDKKRKEEE
390
EAEDKEDEDD
400
RDEDEDEEDE
410
KEEDEEDATG
QAKDEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001669 | acrosomal vesicle |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0060473 | cortical granule |
| Cellular Component | GO:0044194 | cytolytic granule |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0044322 | endoplasmic reticulum quality control compartment |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0042824 | MHC class I peptide loading complex |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0005840 | ribosome |
| Cellular Component | GO:0016529 | sarcoplasmic reticulum |
| Cellular Component | GO:0033018 | sarcoplasmic reticulum lumen |
| Cellular Component | GO:0005790 | smooth endoplasmic reticulum |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0030246 | carbohydrate binding |
| Molecular Function | GO:0001849 | complement component C1q complex binding |
| Molecular Function | GO:0042562 | hormone binding |
| Molecular Function | GO:0005178 | integrin binding |
| Molecular Function | GO:0005506 | iron ion binding |
| Molecular Function | GO:0140313 | molecular sequestering activity |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0050681 | nuclear androgen receptor binding |
| Molecular Function | GO:0005049 | nuclear export signal receptor activity |
| Molecular Function | GO:0042277 | peptide binding |
| Molecular Function | GO:0044183 | protein folding chaperone |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0055007 | cardiac muscle cell differentiation |
| Biological Process | GO:0071257 | cellular response to electrical stimulus |
| Biological Process | GO:0071285 | cellular response to lithium ion |
| Biological Process | GO:0098586 | cellular response to virus |
| Biological Process | GO:0090398 | cellular senescence |
| Biological Process | GO:0030866 | cortical actin cytoskeleton organization |
| Biological Process | GO:0036503 | ERAD pathway |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0033144 | negative regulation of intracellular steroid hormone receptor signaling pathway |
| Biological Process | GO:0045665 | negative regulation of neuron differentiation |
| Biological Process | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0017148 | negative regulation of translation |
| Biological Process | GO:1901164 | negative regulation of trophoblast cell migration |
| Biological Process | GO:0002502 | peptide antigen assembly with MHC class I protein complex |
| Biological Process | GO:0045787 | positive regulation of cell cycle |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:2000510 | positive regulation of dendritic cell chemotaxis |
| Biological Process | GO:0010595 | positive regulation of endothelial cell migration |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:1901224 | positive regulation of non-canonical NF-kappaB signal transduction |
| Biological Process | GO:0050766 | positive regulation of phagocytosis |
| Biological Process | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| Biological Process | GO:0006611 | protein export from nucleus |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0034504 | protein localization to nucleus |
| Biological Process | GO:0051604 | protein maturation |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0040020 | regulation of meiotic nuclear division |
| Biological Process | GO:1904614 | response to biphenyl |
| Biological Process | GO:0032355 | response to estradiol |
| Biological Process | GO:1903416 | response to glycoside |
| Biological Process | GO:1901652 | response to peptide |
| Biological Process | GO:0033574 | response to testosterone |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.