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Overview

Uniprot IDP18420
Protein NameProteasome subunit alpha type-1
Gene NamePsma1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
115 LVSLIGSKTQIPTQR
243 LEERPQRKAQPSQAA
41 ATVGLKSKTHAVLVA
61 SELAAHQKKILHVDN

Function

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)

Protein Sequence

10 MFRNQYDNDV 20 TVWSPQGRIH 30 QIEYAMEAVK 40 QGSATVGLKS 50 KTHAVLVALK 60 RAQSELAAHQ 70 KKILHVDNHI 80 GISIAGLTAD 90 ARLLCNFMRQ 100 ECLDSRFVFD 110 RPLPVSRLVS 120 LIGSKTQIPT 130 QRYGRRPYGV 140 GLLIAGYDDM 150 GPHVFQTCPS 160 ANYFDCRAMS 170 IGARSQSART 180 YLERHMSEFM 190 QCNLDELVKH 200 GLRALRETLP 210 AEQDLTTKNV 220 SIGIVGKDLE 230 FTIYDDDDVS 240 PFLDGLEERP 250 QRKAQPSQAA 260 DEPAEKADEP MEH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000502 proteasome complex
Cellular Component GO:0005839 proteasome core complex
Cellular Component GO:0019773 proteasome core complex, alpha-subunit complex
Cellular Component GO:0008021 synaptic vesicle
Molecular Function GO:0001530 lipopolysaccharide binding
Biological Process GO:0002376 immune system process
Biological Process GO:0002862 negative regulation of inflammatory response to antigenic stimulus
Biological Process GO:0010498 proteasomal protein catabolic process
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0061136 regulation of proteasomal protein catabolic process
Biological Process GO:0006979 response to oxidative stress

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.