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Overview

Uniprot IDP18422
Protein NameProteasome subunit alpha type-3
Gene NamePsma3
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
206 YIVHDEVKDKAFELE
57 VEKLVLSKLYEEGSN

Function

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2

Protein Sequence

10 MSSIGTGYDL 20 SASTFSPDGR 30 VFQVEYAMKA 40 VENSSTAIGI 50 RCKDGVVFGV 60 EKLVLSKLYE 70 EGSNKRLFNV 80 DRHVGMAVAG 90 LLADARSLAD 100 IAREEASNFR 110 SNFGYNIPLK 120 HLADRVAMYV 130 HAYTLYSAVR 140 PFGCSFMLGS 150 YSVNDGAQLY 160 MIDPSGVSYG 170 YWGCAIGKAR 180 QAAKTEIEKL 190 QMKEMTCRDV 200 VKEVAKIIYI 210 VHDEVKDKAF 220 ELELSWVGEL 230 TKGRHEIVPK 240 DVREEAEKYA 250 KESLKEEDES DDDNM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000502 proteasome complex
Cellular Component GO:0005839 proteasome core complex
Cellular Component GO:0019773 proteasome core complex, alpha-subunit complex
Cellular Component GO:0008021 synaptic vesicle
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0010498 proteasomal protein catabolic process
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0061136 regulation of proteasomal protein catabolic process
Biological Process GO:0006979 response to oxidative stress

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.