Search Results
Overview
| Uniprot ID | P18440 |
|---|---|
| Protein Name | Arylamine N-acetyltransferase 1 |
| Gene Name | NAT1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 188 | LEDSKYRKIYSFTLK |
Function
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens
Protein Sequence
10
MDIEAYLERI
20
GYKKSRNKLD
30
LETLTDILQH
40
QIRAVPFENL
50
NIHCGDAMDL
60
GLEAIFDQVV
70
RRNRGGWCLQ
80
VNHLLYWALT
90
TIGFETTMLG
100
GYVYSTPAKK
110
YSTGMIHLLL
120
QVTIDGRNYI
130
VDAGFGRSYQ
140
MWQPLELISG
150
KDQPQVPCVF
160
RLTEENGFWY
170
LDQIRREQYI
180
PNEEFLHSDL
190
LEDSKYRKIY
200
SFTLKPRTIE
210
DFESMNTYLQ
220
TSPSSVFTSK
230
SFCSLQTPDG
240
VHCLVGFTLT
250
HRRFNYKDNT
260
DLIEFKTLSE
270
EEIEKVLKNI
280
FNISLQRKLV
290
PKHGDRFFTI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0004060 | arylamine N-acetyltransferase activity |
| Molecular Function | GO:0019707 | protein-cysteine S-acyltransferase activity |
| Biological Process | GO:0006805 | xenobiotic metabolic process |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.