Search Results

Overview

Uniprot IDP18614
Protein NameIntegrin alpha-1
Gene NameItga1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1044 PFGINSGKKMTISKS
1050 GKKMTISKSEVLKRG
832 EKSLLIVKSQHDKFN

Function

Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity)

Protein Sequence

10 MVPRRPASLE 20 VTVACIWLLT 30 VILGFCVSFN 40 VDVKNSMSFS 50 GPVEDMFGYT 60 VQQYENEEGK 70 WVLIGSPLVG 80 QPKARTGDVY 90 KCPVGRERAM 100 PCVKLDLPVN 110 TSIPNVTEIK 120 ENMTFGSTLV 130 TNPNGGFLAC 140 GPLYAYRCGH 150 LHYTTGICSD 160 VSPTFQVVNS 170 FAPVQECSTQ 180 LDIVIVLDGS 190 NSIYPWESVI 200 AFLNDLLKRM 210 DIGPKQTQVG 220 IVQYGENVTH 230 EFNLNKYSST 240 EEVLVAANKI 250 GRQGGLQTMT 260 ALGIDTARKE 270 AFTEARGARR 280 GVKKVMVIVT 290 DGESHDNYRL 300 KQVIQDCEDE 310 NIQRFSIAIL 320 GHYNRGNLST 330 EKFVEEIKSI 340 ASEPTEKHFF 350 NVSDELALVT 360 IVKALGERIF 370 ALEATADQSA 380 ASFEMEMSQT 390 GFSAHYSQDW 400 VMLGAVGAYD 410 WNGTVVMQKA 420 NQMVIPHNTT 430 FQTEPAKMNE 440 PLASYLGYTV 450 NSATIPGDVL 460 YIAGQPRYNH 470 TGQVVIYKME 480 DGNINILQTL 490 GGEQIGSYFG 500 SVLTTIDIDK 510 DSYTDLLLVG 520 APMYMGTEKE 530 EQGKVYVYAV 540 NQTRFEYQMS 550 LEPIRQTCCS 560 SLKDNSCTKE 570 NKNEPCGARF 580 GTAIAAVKDL 590 NVDGFNDVVI 600 GAPLEDDHAG 610 AVYIYHGSGK 620 TIREAYAQRI 630 PSGGDGKTLK 640 FFGQSIHGEM 650 DLNGDGLTDV 660 TIGGLGGAAL 670 FWARDVAVVK 680 VTMNFEPNKV 690 NIQKKNCRVE 700 GKETVCINAT 710 MCFHVKLKSK 720 EDSIYEADLQ 730 YRVTLDSLRQ 740 ISRSFFSGTQ 750 ERKIQRNITV 760 RESECIRHSF 770 YMLDKHDFQD 780 SVRVTLDFNL 790 TDPENGPVLD 800 DALPNSVHEH 810 IPFAKDCGNK 820 ERCISDLTLN 830 VSTTEKSLLI 840 VKSQHDKFNV 850 SLTVKNKGDS 860 AYNTRTVVQH 870 SPNLIFSGIE 880 EIQKDSCESN 890 QNITCRVGYP 900 FLRAGETVTF 910 KIIFQFNTSH 920 LSENAIIHLS 930 ATSDSEEPLE 940 SLNDNEVNIS 950 IPVKYEVGLQ 960 FYSSASEHHI 970 SVAANETIPE 980 FINSTEDIGN 990 EINVFYTIRK 1000 RGHFPMPELQ 1010 LSISFPNLTA 1020 DGYPVLYPIG 1030 WSSSDNVNCR 1040 PRSLEDPFGI 1050 NSGKKMTISK 1060 SEVLKRGTIQ 1070 DCSSTCGVAT 1080 ITCSLLPSDL 1090 SQVNVSLLLW 1100 KPTFIRAHFS 1110 SLNLTLRGEL 1120 KSENSSLTLS 1130 SSNRKRELAI 1140 QISKDGLPGR 1150 VPLWVILLSA 1160 FAGLLLLMLL 1170 ILALWKIGFF 1180 KRPLKKKMEK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0001669 acrosomal vesicle
Cellular Component GO:0045178 basal part of cell
Cellular Component GO:0009986 cell surface
Cellular Component GO:0009897 external side of plasma membrane
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0034665 integrin alpha1-beta1 complex
Cellular Component GO:0043204 perikaryon
Molecular Function GO:0005518 collagen binding
Molecular Function GO:0098639 collagen binding involved in cell-matrix adhesion
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0019211 phosphatase activator activity
Molecular Function GO:0019903 protein phosphatase binding
Molecular Function GO:0038023 signaling receptor activity
Molecular Function GO:0005102 signaling receptor binding
Biological Process GO:0007155 cell adhesion
Biological Process GO:0060326 cell chemotaxis
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0045123 cellular extravasation
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
Biological Process GO:0048812 neuron projection morphogenesis
Biological Process GO:0030593 neutrophil chemotaxis
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:0043525 positive regulation of neuron apoptotic process
Biological Process GO:0042311 vasodilation

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.