Overview
| Uniprot ID | P18754 |
|---|
| Protein Name | Regulator of chromosome condensation |
|---|
| Gene Name | RCC1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 19 |
PPADAIPKSKKVKVS |
| 21 |
ADAIPKSKKVKVSHR |
Function
Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:11336674, PubMed:17435751, PubMed:1944575, PubMed:20668449, PubMed:22215983, PubMed:29042532). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580)
Protein Sequence
10
MSPKRIAKRR
20
SPPADAIPKS
30
KKVKVSHRSH
40
STEPGLVLTL
50
GQGDVGQLGL
60
GENVMERKKP
70
ALVSIPEDVV
80
QAEAGGMHTV
90
CLSKSGQVYS
100
FGCNDEGALG
110
RDTSVEGSEM
120
VPGKVELQEK
130
VVQVSAGDSH
140
TAALTDDGRV
150
FLWGSFRDNN
160
GVIGLLEPMK
170
KSMVPVQVQL
180
DVPVVKVASG
190
NDHLVMLTAD
200
GDLYTLGCGE
210
QGQLGRVPEL
220
FANRGGRQGL
230
ERLLVPKCVM
240
LKSRGSRGHV
250
RFQDAFCGAY
260
FTFAISHEGH
270
VYGFGLSNYH
280
QLGTPGTESC
290
FIPQNLTSFK
300
NSTKSWVGFS
310
GGQHHTVCMD
320
SEGKAYSLGR
330
AEYGRLGLGE
340
GAEEKSIPTL
350
ISRLPAVSSV
360
ACGASVGYAV
370
TKDGRVFAWG
380
MGTNYQLGTG
390
QDEDAWSPVE
400
MMGKQLENRV
410
VLSVSSGGQH
420
TVLLVKDKEQ
S
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0005694 |
chromosome |
| Cellular Component |
GO:0000794 |
condensed nuclear chromosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Molecular Function |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
| Molecular Function |
GO:0042393 |
histone binding |
| Molecular Function |
GO:0031492 |
nucleosomal DNA binding |
| Molecular Function |
GO:0031491 |
nucleosome binding |
| Molecular Function |
GO:0046982 |
protein heterodimerization activity |
| Molecular Function |
GO:0031267 |
small GTPase binding |
| Molecular Function |
GO:0043199 |
sulfate binding |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0007059 |
chromosome segregation |
| Biological Process |
GO:0000082 |
G1/S transition of mitotic cell cycle |
| Biological Process |
GO:0007084 |
mitotic nuclear membrane reassembly |
| Biological Process |
GO:0007052 |
mitotic spindle organization |
| Biological Process |
GO:0090068 |
positive regulation of cell cycle process |
| Biological Process |
GO:0007346 |
regulation of mitotic cell cycle |
| Biological Process |
GO:0007088 |
regulation of mitotic nuclear division |
| Biological Process |
GO:1901673 |
regulation of mitotic spindle assembly |
| Biological Process |
GO:0051225 |
spindle assembly |
| Biological Process |
GO:0016032 |
viral process |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.