Search Results

Overview

Uniprot IDP18858
Protein NameDNA ligase 1
Gene NameLIG1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
12 IMSFFHPKKEGKAKK
13 MSFFHPKKEGKAKKP
192 PKPLKTSKAETPTES
226 KPPRRAPKTLSSFFT
36 RETEPPPKAALKEWN

Function

DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination

Protein Sequence

10 MQRSIMSFFH 20 PKKEGKAKKP 30 EKEASNSSRE 40 TEPPPKAALK 50 EWNGVVSESD 60 SPVKRPGRKA 70 ARVLGSEGEE 80 EDEALSPAKG 90 QKPALDCSQV 100 SPPRPATSPE 110 NNASLSDTSP 120 MDSSPSGIPK 130 RRTARKQLPK 140 RTIQEVLEEQ 150 SEDEDREAKR 160 KKEEEEEETP 170 KESLTEAEVA 180 TEKEGEDGDQ 190 PTTPPKPLKT 200 SKAETPTESV 210 SEPEVATKQE 220 LQEEEEQTKP 230 PRRAPKTLSS 240 FFTPRKPAVK 250 KEVKEEEPGA 260 PGKEGAAEGP 270 LDPSGYNPAK 280 NNYHPVEDAC 290 WKPGQKVPYL 300 AVARTFEKIE 310 EVSARLRMVE 320 TLSNLLRSVV 330 ALSPPDLLPV 340 LYLSLNHLGP 350 PQQGLELGVG 360 DGVLLKAVAQ 370 ATGRQLESVR 380 AEAAEKGDVG 390 LVAENSRSTQ 400 RLMLPPPPLT 410 ASGVFSKFRD 420 IARLTGSAST 430 AKKIDIIKGL 440 FVACRHSEAR 450 FIARSLSGRL 460 RLGLAEQSVL 470 AALSQAVSLT 480 PPGQEFPPAM 490 VDAGKGKTAE 500 ARKTWLEEQG 510 MILKQTFCEV 520 PDLDRIIPVL 530 LEHGLERLPE 540 HCKLSPGIPL 550 KPMLAHPTRG 560 ISEVLKRFEE 570 AAFTCEYKYD 580 GQRAQIHALE 590 GGEVKIFSRN 600 QEDNTGKYPD 610 IISRIPKIKL 620 PSVTSFILDT 630 EAVAWDREKK 640 QIQPFQVLTT 650 RKRKEVDASE 660 IQVQVCLYAF 670 DLIYLNGESL 680 VREPLSRRRQ 690 LLRENFVETE 700 GEFVFATSLD 710 TKDIEQIAEF 720 LEQSVKDSCE 730 GLMVKTLDVD 740 ATYEIAKRSH 750 NWLKLKKDYL 760 DGVGDTLDLV 770 VIGAYLGRGK 780 RAGRYGGFLL 790 ASYDEDSEEL 800 QAICKLGTGF 810 SDEELEEHHQ 820 SLKALVLPSP 830 RPYVRIDGAV 840 IPDHWLDPSA 850 VWEVKCADLS 860 LSPIYPAARG 870 LVDSDKGISL 880 RFPRFIRVRE 890 DKQPEQATTS 900 AQVACLYRKQ 910 SQIQNQQGED SGSDPEDTY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Biological Process GO:0006284 base-excision repair
Biological Process GO:0006287 base-excision repair, gap-filling
Biological Process GO:0051301 cell division
Biological Process GO:0071897 DNA biosynthetic process
Biological Process GO:0006310 DNA recombination
Biological Process GO:0006281 DNA repair
Biological Process GO:0006273 lagging strand elongation
Biological Process GO:0006298 mismatch repair
Biological Process GO:1903461 Okazaki fragment processing involved in mitotic DNA replication
Biological Process GO:0032201 telomere maintenance via semi-conservative replication
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003910 DNA ligase (ATP) activity
Molecular Function GO:0003909 DNA ligase activity
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0009653 anatomical structure morphogenesis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.