Search Results
Overview
| Uniprot ID | P19132 |
|---|---|
| Protein Name | Ferritin heavy chain |
| Gene Name | Fth1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 147 | NEQVKSIKELGDHVT |
| 69 | EEREHAEKLMKLQNQ |
| 72 | EHAEKLMKLQNQRGG |
Function
Stores iron in a soluble, non-toxic, readily available form (By similarity). Important for iron homeostasis (By similarity). Has ferroxidase activity (By similarity). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity). Also plays a role in delivery of iron to cells (By similarity). Mediates iron uptake in capsule cells of the developing kidney (By similarity). Delivery to lysosomes is mediated by the cargo receptor NCOA4 for autophagic degradation and release of iron (By similarity)
Protein Sequence
10
MTTASPSQVR
20
QNYHQDSEAA
30
INRQINLELY
40
ASYVYLSMSC
50
YFDRDDVALK
60
NFAKYFLHQS
70
HEEREHAEKL
80
MKLQNQRGGR
90
IFLQDIKKPD
100
RDDWESGLNA
110
MRCALHLEKS
120
VNQSLLELHK
130
LATDKNDPHL
140
CDFIETHYLN
150
EQVKSIKELG
160
DHVTNLRKMG
170
APESGMAEYL
180
FDKHTLGHGD
ES
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0044754 | autolysosome |
| Cellular Component | GO:0005776 | autophagosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0008199 | ferric iron binding |
| Molecular Function | GO:0008198 | ferrous iron binding |
| Molecular Function | GO:0004322 | ferroxidase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005506 | iron ion binding |
| Molecular Function | GO:0140315 | iron ion sequestering activity |
| Biological Process | GO:0006955 | immune response |
| Biological Process | GO:0006879 | intracellular iron ion homeostasis |
| Biological Process | GO:0006826 | iron ion transport |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0110076 | negative regulation of ferroptosis |
| Biological Process | GO:0048147 | negative regulation of fibroblast proliferation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.