Search Results
Overview
| Uniprot ID | P19174 |
|---|---|
| Protein Name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 |
| Gene Name | PLCG1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 68 | TWSRGADKIEGAIDI |
Function
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity)
Protein Sequence
10
MAGAASPCAN
20
GCGPGAPSDA
30
EVLHLCRSLE
40
VGTVMTLFYS
50
KKSQRPERKT
60
FQVKLETRQI
70
TWSRGADKIE
80
GAIDIREIKE
90
IRPGKTSRDF
100
DRYQEDPAFR
110
PDQSHCFVIL
120
YGMEFRLKTL
130
SLQATSEDEV
140
NMWIKGLTWL
150
MEDTLQAPTP
160
LQIERWLRKQ
170
FYSVDRNRED
180
RISAKDLKNM
190
LSQVNYRVPN
200
MRFLRERLTD
210
LEQRSGDITY
220
GQFAQLYRSL
230
MYSAQKTMDL
240
PFLEASTLRA
250
GERPELCRVS
260
LPEFQQFLLD
270
YQGELWAVDR
280
LQVQEFMLSF
290
LRDPLREIEE
300
PYFFLDEFVT
310
FLFSKENSVW
320
NSQLDAVCPD
330
TMNNPLSHYW
340
ISSSHNTYLT
350
GDQFSSESSL
360
EAYARCLRMG
370
CRCIELDCWD
380
GPDGMPVIYH
390
GHTLTTKIKF
400
SDVLHTIKEH
410
AFVASEYPVI
420
LSIEDHCSIA
430
QQRNMAQYFK
440
KVLGDTLLTK
450
PVEISADGLP
460
SPNQLKRKIL
470
IKHKKLAEGS
480
AYEEVPTSMM
490
YSENDISNSI
500
KNGILYLEDP
510
VNHEWYPHYF
520
VLTSSKIYYS
530
EETSSDQGNE
540
DEEEPKEVSS
550
STELHSNEKW
560
FHGKLGAGRD
570
GRHIAERLLT
580
EYCIETGAPD
590
GSFLVRESET
600
FVGDYTLSFW
610
RNGKVQHCRI
620
HSRQDAGTPK
630
FFLTDNLVFD
640
SLYDLITHYQ
650
QVPLRCNEFE
660
MRLSEPVPQT
670
NAHESKEWYH
680
ASLTRAQAEH
690
MLMRVPRDGA
700
FLVRKRNEPN
710
SYAISFRAEG
720
KIKHCRVQQE
730
GQTVMLGNSE
740
FDSLVDLISY
750
YEKHPLYRKM
760
KLRYPINEEA
770
LEKIGTAEPD
780
YGALYEGRNP
790
GFYVEANPMP
800
TFKCAVKALF
810
DYKAQREDEL
820
TFIKSAIIQN
830
VEKQEGGWWR
840
GDYGGKKQLW
850
FPSNYVEEMV
860
NPVALEPERE
870
HLDENSPLGD
880
LLRGVLDVPA
890
CQIAIRPEGK
900
NNRLFVFSIS
910
MASVAHWSLD
920
VAADSQEELQ
930
DWVKKIREVA
940
QTADARLTEG
950
KIMERRKKIA
960
LELSELVVYC
970
RPVPFDEEKI
980
GTERACYRDM
990
SSFPETKAEK
1000
YVNKAKGKKF
1010
LQYNRLQLSR
1020
IYPKGQRLDS
1030
SNYDPLPMWI
1040
CGSQLVALNF
1050
QTPDKPMQMN
1060
QALFMTGRHC
1070
GYVLQPSTMR
1080
DEAFDPFDKS
1090
SLRGLEPCAI
1100
SIEVLGARHL
1110
PKNGRGIVCP
1120
FVEIEVAGAE
1130
YDSTKQKTEF
1140
VVDNGLNPVW
1150
PAKPFHFQIS
1160
NPEFAFLRFV
1170
VYEEDMFSDQ
1180
NFLAQATFPV
1190
KGLKTGYRAV
1200
PLKNNYSEDL
1210
ELASLLIKID
1220
IFPAKENGDL
1230
SPFSGTSLRE
1240
RGSDASGQLF
1250
HGRAREGSFE
1260
SRYQQPFEDF
1270
RISQEHLADH
1280
FDSRERRAPR
1290
RTRVNGDNRL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0042995 | cell projection |
| Cellular Component | GO:0008180 | COP9 signalosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0032587 | ruffle membrane |
| Molecular Function | GO:0004629 | C-type glycerophospholipase activity |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005085 | guanyl-nucleotide exchange factor activity |
| Molecular Function | GO:0140324 | lysophospholipase C activity |
| Molecular Function | GO:0005168 | neurotrophin TRKA receptor binding |
| Molecular Function | GO:0120548 | phosphatidylinositol phospholipase C activity |
| Molecular Function | GO:0004435 | phosphatidylinositol-4,5-bisphosphate phospholipase C activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Biological Process | GO:0019722 | calcium-mediated signaling |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0071364 | cellular response to epidermal growth factor stimulus |
| Biological Process | GO:0007173 | epidermal growth factor receptor signaling pathway |
| Biological Process | GO:0038095 | Fc-epsilon receptor signaling pathway |
| Biological Process | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus |
| Biological Process | GO:0046488 | phosphatidylinositol metabolic process |
| Biological Process | GO:0048015 | phosphatidylinositol-mediated signaling |
| Biological Process | GO:0009395 | phospholipid catabolic process |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| Biological Process | GO:2000353 | positive regulation of endothelial cell apoptotic process |
| Biological Process | GO:0010634 | positive regulation of epithelial cell migration |
| Biological Process | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol |
| Biological Process | GO:1905564 | positive regulation of vascular endothelial cell proliferation |
| Biological Process | GO:0051209 | release of sequestered calcium ion into cytosol |
| Biological Process | GO:0050852 | T cell receptor signaling pathway |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.