Overview
| Uniprot ID | P19224 |
|---|
| Protein Name | UDP-glucuronosyltransferase 1A6 |
|---|
| Gene Name | UGT1A6 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 140 |
RDTLNFFKESKFDAL |
| 317 |
VSEIPEKKAMAIADA |
| 433 |
LKAVINDKSYKENIM |
| 436 |
VINDKSYKENIMRLS |
| 76 |
ESKYYTRKIYPVPYD |
Function
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to facilitate their inactivation and excretion from the body (PubMed:15231852, PubMed:21422672). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:15231852, PubMed:21422672). Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE and 20-HETE (PubMed:15231852). Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate (By similarity). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group (PubMed:21422672)
Protein Sequence
10
MACLLRSFQR
20
ISAGVFFLAL
30
WGMVVGDKLL
40
VVPQDGSHWL
50
SMKDIVEVLS
60
DRGHEIVVVV
70
PEVNLLLKES
80
KYYTRKIYPV
90
PYDQEELKNR
100
YQSFGNNHFA
110
ERSFLTAPQT
120
EYRNNMIVIG
130
LYFINCQSLL
140
QDRDTLNFFK
150
ESKFDALFTD
160
PALPCGVILA
170
EYLGLPSVYL
180
FRGFPCSLEH
190
TFSRSPDPVS
200
YIPRCYTKFS
210
DHMTFSQRVA
220
NFLVNLLEPY
230
LFYCLFSKYE
240
ELASAVLKRD
250
VDIITLYQKV
260
SVWLLRYDFV
270
LEYPRPVMPN
280
MVFIGGINCK
290
KRKDLSQEFE
300
AYINASGEHG
310
IVVFSLGSMV
320
SEIPEKKAMA
330
IADALGKIPQ
340
TVLWRYTGTR
350
PSNLANNTIL
360
VKWLPQNDLL
370
GHPMTRAFIT
380
HAGSHGVYES
390
ICNGVPMVMM
400
PLFGDQMDNA
410
KRMETKGAGV
420
TLNVLEMTSE
430
DLENALKAVI
440
NDKSYKENIM
450
RLSSLHKDRP
460
VEPLDLAVFW
470
VEFVMRHKGA
480
PHLRPAAHDL
490
TWYQYHSLDV
500
IGFLLAVVLT
510
VAFITFKCCA
520
YGYRKCLGKK
530
GRVKKAHKSK
TH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Molecular Function |
GO:0019899 |
enzyme binding |
| Molecular Function |
GO:0004857 |
enzyme inhibitor activity |
| Molecular Function |
GO:0015020 |
glucuronosyltransferase activity |
| Molecular Function |
GO:0046982 |
protein heterodimerization activity |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0008194 |
UDP-glycosyltransferase activity |
| Biological Process |
GO:0071385 |
cellular response to glucocorticoid stimulus |
| Biological Process |
GO:0008210 |
estrogen metabolic process |
| Biological Process |
GO:0051552 |
flavone metabolic process |
| Biological Process |
GO:0019585 |
glucuronate metabolic process |
| Biological Process |
GO:0001889 |
liver development |
| Biological Process |
GO:0045922 |
negative regulation of fatty acid metabolic process |
| Biological Process |
GO:0016125 |
sterol metabolic process |
| Biological Process |
GO:0006805 |
xenobiotic metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.