Search Results
Overview
| Uniprot ID | P19234 |
|---|---|
| Protein Name | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial |
| Gene Name | Ndufv2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 214 | LRAGKVPKPGPRSGR |
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Parts of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone. Contains one iron-sulfur cluster
Protein Sequence
10
MFSLALRARA
20
SGLTAQWGRH
30
ARNLHKTAVQ
40
NGAGGALFVH
50
RDTPENNPDT
60
PFDFTPENYE
70
RIEAIVRNYP
80
EGHRAAAVLP
90
VLDLAQRQNG
100
WLPISAMNKV
110
AEVLQVPPMR
120
VYEVATFYTM
130
YNRKPVGKYH
140
IQVCTTTPCM
150
LRDSDSILET
160
LQRKLGIKVG
170
ETTPDKLFTL
180
IEVECLGACV
190
NAPMVQINDD
200
YYEDLTPKDI
210
EEIIDELRAG
220
KVPKPGPRSG
230
RFCCEPAGGL
240
TSLTEPPKGP
GFGVQAGL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045271 | respiratory chain complex I |
| Molecular Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
| Molecular Function | GO:0016491 | oxidoreductase activity |
| Biological Process | GO:0048738 | cardiac muscle tissue development |
| Biological Process | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
| Biological Process | GO:0007399 | nervous system development |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.