Search Results

Overview

Uniprot ID	P19404
Protein Name	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
Gene Name	NDUFV2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
154	SILEAIQKKLGIKVG
159	IQKKLGIKVGETTPD
61	DFTPENYKRIEAIVK
75	KNYPEGHKAAAVLPV

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (Probable). Parts of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone (Probable). Contains one iron-sulfur cluster (Probable)

Protein Sequence

10 MFFSAALRAR 20 AAGLTAHWGR 30 HVRNLHKTVM 40 QNGAGGALFV 50 HRDTPENNPD 60 TPFDFTPENY 70 KRIEAIVKNY 80 PEGHKAAAVL 90 PVLDLAQRQN 100 GWLPISAMNK 110 VAEVLQVPPM 120 RVYEVATFYT 130 MYNRKPVGKY 140 HIQVCTTTPC 150 MLRNSDSILE 160 AIQKKLGIKV 170 GETTPDKLFT 180 LIEVECLGAC 190 VNAPMVQIND 200 NYYEDLTAKD 210 IEEIIDELKA 220 GKIPKPGPRS 230 GRFSCEPAGG 240 LTSLTEPPKG PGFGVQAGL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0045271	respiratory chain complex I
Molecular Function	GO:0051537	2 iron, 2 sulfur cluster binding
Molecular Function	GO:0009055	electron transfer activity
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0008137	NADH dehydrogenase (ubiquinone) activity
Molecular Function	GO:0016491	oxidoreductase activity
Biological Process	GO:0009060	aerobic respiration
Biological Process	GO:0048738	cardiac muscle tissue development
Biological Process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone
Biological Process	GO:0007399	nervous system development
Biological Process	GO:0042776	proton motive force-driven mitochondrial ATP synthesis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.