Overview
| Uniprot ID | P19440 |
|---|
| Protein Name | Glutathione hydrolase 1 proenzyme |
|---|
| Gene Name | GGT1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 181 |
LAAALENKRTVIEQQ |
| 309 |
SVESPEQKGLTYHRI |
Function
Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate, MCTR1) and other gamma-glutamyl compounds (such as leukotriene C4, LTC4) (PubMed:17924658, PubMed:21447318, PubMed:27791009). The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases (PubMed:27791009). In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound (PubMed:17924658, PubMed:21447318, PubMed:7673200, PubMed:7759490, PubMed:8095045, PubMed:8827453). Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4
Protein Sequence
10
MKKKLVVLGL
20
LAVVLVLVIV
30
GLCLWLPSAS
40
KEPDNHVYTR
50
AAVAADAKQC
60
SKIGRDALRD
70
GGSAVDAAIA
80
ALLCVGLMNA
90
HSMGIGGGLF
100
LTIYNSTTRK
110
AEVINAREVA
120
PRLAFATMFN
130
SSEQSQKGGL
140
SVAVPGEIRG
150
YELAHQRHGR
160
LPWARLFQPS
170
IQLARQGFPV
180
GKGLAAALEN
190
KRTVIEQQPV
200
LCEVFCRDRK
210
VLREGERLTL
220
PQLADTYETL
230
AIEGAQAFYN
240
GSLTAQIVKD
250
IQAAGGIVTA
260
EDLNNYRAEL
270
IEHPLNISLG
280
DVVLYMPSAP
290
LSGPVLALIL
300
NILKGYNFSR
310
ESVESPEQKG
320
LTYHRIVEAF
330
RFAYAKRTLL
340
GDPKFVDVTE
350
VVRNMTSEFF
360
AAQLRAQISD
370
DTTHPISYYK
380
PEFYTPDDGG
390
TAHLSVVAED
400
GSAVSATSTI
410
NLYFGSKVRS
420
PVSGILFNNE
430
MDDFSSPSIT
440
NEFGVPPSPA
450
NFIQPGKQPL
460
SSMCPTIMVG
470
QDGQVRMVVG
480
AAGGTQITTA
490
TALAIIYNLW
500
FGYDVKRAVE
510
EPRLHNQLLP
520
NVTTVERNID
530
QAVTAALETR
540
HHHTQIASTF
550
IAVVQAIVRT
560
AGGWAAASDS
RKGGEPAGY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0036374 |
glutathione hydrolase activity |
| Molecular Function |
GO:0103068 |
leukotriene C4 gamma-glutamyl transferase activity |
| Molecular Function |
GO:0002951 |
leukotriene-C(4) hydrolase activity |
| Molecular Function |
GO:0000048 |
peptidyltransferase activity |
| Biological Process |
GO:0006520 |
amino acid metabolic process |
| Biological Process |
GO:0006631 |
fatty acid metabolic process |
| Biological Process |
GO:0006536 |
glutamate metabolic process |
| Biological Process |
GO:0006750 |
glutathione biosynthetic process |
| Biological Process |
GO:0006751 |
glutathione catabolic process |
| Biological Process |
GO:0019344 |
L-cysteine biosynthetic process |
| Biological Process |
GO:1901750 |
leukotriene D4 biosynthetic process |
| Biological Process |
GO:0006691 |
leukotriene metabolic process |
| Biological Process |
GO:0031179 |
peptide modification |
| Biological Process |
GO:0006508 |
proteolysis |
| Biological Process |
GO:0002682 |
regulation of immune system process |
| Biological Process |
GO:0050727 |
regulation of inflammatory response |
| Biological Process |
GO:0007283 |
spermatogenesis |
| Biological Process |
GO:0031638 |
zymogen activation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.