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Overview

Uniprot ID	P19511
Protein Name	ATP synthase peripheral stalk subunit b, mitochondrial
Gene Name	Atp5pb
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
131	IDKLNEEKIAQLEEI
139	IAQLEEIKQSSMKQI
144	EIKQSSMKQIQDAIN
154	QDAINREKAQQALVQ
162	AQQALVQKRHYLFDV
210	VQDMMRRKEGEHMIN
233	SISAQQEKETIAKCI
238	QEKETIAKCIGDLKM

Function

Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity)

Protein Sequence

10 MLSRVVLSAA 20 ATAAPCLKNA 30 AVLGPGVLQA 40 TRVFHTGQPR 50 LAPLPPLPEY 60 GGKVRLGLIP 70 EEFFQFLYPK 80 TGVTGPYVLG 90 TGLSLYFLSK 100 EIYVITPETF 110 STISVVGLIV 120 YVIKKYGASI 130 GEFIDKLNEE 140 KIAQLEEIKQ 150 SSMKQIQDAI 160 NREKAQQALV 170 QKRHYLFDVQ 180 RNNIALALEV 190 TYRERLHKAY 200 KEVKNRLDYH 210 ISVQDMMRRK 220 EGEHMINWVE 230 KHVIQSISAQ 240 QEKETIAKCI 250 GDLKMLAKKA QAQPIM

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0045259	proton-transporting ATP synthase complex
Molecular Function	GO:0044877	protein-containing complex binding
Molecular Function	GO:0015078	proton transmembrane transporter activity
Biological Process	GO:0071456	cellular response to hypoxia
Biological Process	GO:0015986	proton motive force-driven ATP synthesis
Biological Process	GO:0042776	proton motive force-driven mitochondrial ATP synthesis

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.