Search Results
Overview
| Uniprot ID | P19527 |
|---|---|
| Protein Name | Neurofilament light polypeptide |
| Gene Name | Nefl |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 157 | AEDATNEKQALQGER |
| 197 | GRLMEARKGADEAAL |
| 224 | MDEIAFLKKVHEEEI |
| 268 | DIRAQYEKLAAKNMQ |
| 272 | QYEKLAAKNMQNAEE |
| 282 | QNAEEWFKSRFTVLT |
| 294 | VLTESAAKNTDAVRA |
| 303 | TDAVRAAKDEVSESR |
| 316 | SRRLLKAKTLEIEAC |
| 363 | ENELRSTKSEMARYL |
| 371 | SEMARYLKEYQDLLN |
| 91 | KSIRTQEKAQLQDLN |
Function
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity)
Protein Sequence
10
MSSFSYEPYF
20
STSYKRRYVE
30
TPRVHISSVR
40
SGYSTARSAY
50
SSYSAPVSSS
60
LSVRRSYSSS
70
SGSLMPSLEN
80
LDLSQVAAIS
90
NDLKSIRTQE
100
KAQLQDLNDR
110
FASFIERVHE
120
LEQQNKVLEA
130
ELLVLRQKHS
140
EPSRFRALYE
150
QEIRDLRLAA
160
EDATNEKQAL
170
QGEREGLEET
180
LRNLQARYEE
190
EVLSREDAEG
200
RLMEARKGAD
210
EAALARAELE
220
KRIDSLMDEI
230
AFLKKVHEEE
240
IAELQAQIQY
250
AQISVEMDVS
260
SKPDLSAALK
270
DIRAQYEKLA
280
AKNMQNAEEW
290
FKSRFTVLTE
300
SAAKNTDAVR
310
AAKDEVSESR
320
RLLKAKTLEI
330
EACRGMNEAL
340
EKQLQELEDK
350
QNADISAMQD
360
TINKLENELR
370
STKSEMARYL
380
KEYQDLLNVK
390
MALDIEIAAY
400
RKLLEGEETR
410
LSFTSVGSIT
420
SGYSQSSQVF
430
GRSAYSGLQS
440
SSYLMSARAF
450
PAYYTSHVQE
460
EQSEVEETIE
470
ATKAEEAKDE
480
PPSEGEAEEE
490
EKEKEEGEEE
500
EGAEEEEAAK
510
DESEDAKEEE
520
GGEGEEEDTK
530
ESEEEEKKEE
540
SAGEEQAAKK
KD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0140693 | molecular condensate scaffold activity |
| Molecular Function | GO:0043274 | phospholipase binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Molecular Function | GO:0099184 | structural constituent of postsynaptic intermediate filament cytoskeleton |
| Molecular Function | GO:0015631 | tubulin binding |
| Biological Process | GO:0008089 | anterograde axonal transport |
| Biological Process | GO:0019896 | axonal transport of mitochondrion |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:0021766 | hippocampus development |
| Biological Process | GO:0045110 | intermediate filament bundle assembly |
| Biological Process | GO:0045109 | intermediate filament organization |
| Biological Process | GO:0045107 | intermediate filament polymerization |
| Biological Process | GO:0045105 | intermediate filament polymerization or depolymerization |
| Biological Process | GO:0040011 | locomotion |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:0033693 | neurofilament bundle assembly |
| Biological Process | GO:0060052 | neurofilament cytoskeleton organization |
| Biological Process | GO:0050885 | neuromuscular process controlling balance |
| Biological Process | GO:0048812 | neuron projection morphogenesis |
| Biological Process | GO:0014012 | peripheral nervous system axon regeneration |
| Biological Process | GO:0050772 | positive regulation of axonogenesis |
| Biological Process | GO:0099170 | postsynaptic modulation of chemical synaptic transmission |
| Biological Process | GO:0051258 | protein polymerization |
| Biological Process | GO:0031133 | regulation of axon diameter |
| Biological Process | GO:0090128 | regulation of synapse maturation |
| Biological Process | GO:1903937 | response to acrylamide |
| Biological Process | GO:0051412 | response to corticosterone |
| Biological Process | GO:0043434 | response to peptide hormone |
| Biological Process | GO:1903935 | response to sodium arsenite |
| Biological Process | GO:0009636 | response to toxic substance |
| Biological Process | GO:0008090 | retrograde axonal transport |
| Biological Process | GO:0021510 | spinal cord development |
| Cellular Component | GO:1904115 | axon cytoplasm |
| Cellular Component | GO:0098981 | cholinergic synapse |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0005882 | intermediate filament |
| Cellular Component | GO:0005883 | neurofilament |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0099160 | postsynaptic intermediate filament cytoskeleton |
| Cellular Component | GO:0099182 | presynaptic intermediate filament cytoskeleton |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.