Overview
| Uniprot ID | P19620 |
|---|
| Protein Name | Annexin A2 |
|---|
| Gene Name | ANXA2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 115 |
QYDASELKASMKGLG |
| 148 |
QEINRVYKEMYKTDL |
| 152 |
RVYKEMYKTDLEKDI |
| 157 |
MYKTDLEKDIISDTS |
| 169 |
DTSGDFRKLMVALAK |
| 176 |
KLMVALAKGRRAEDG |
| 204 |
DLYDAGVKRKGTDVP |
| 206 |
YDAGVKRKGTDVPKW |
| 227 |
RSVCHLQKVFERYKS |
| 233 |
QKVFERYKSYSPYDM |
| 245 |
YDMLESIKKEVKGDL |
| 279 |
DRLYDSMKGKGTRDK |
| 302 |
RSEVDMLKIRSEFKR |
| 313 |
EFKRKYGKSLYNYIQ |
| 324 |
NYIQQDTKGDYQKAL |
| 47 |
LNIETAIKTKGVDEV |
| 49 |
IETAIKTKGVDEVTI |
| 81 |
AYQRRTKKELASALK |
Function
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity)
Protein Sequence
10
MSTVHEILCK
20
LSLEGDHSTP
30
ASAYGSVKAY
40
TNFDAERDAL
50
NIETAIKTKG
60
VDEVTIVNIL
70
TNRSNEQRQD
80
IAFAYQRRTK
90
KELASALKSA
100
LSGHLETVIL
110
GLLKTPAQYD
120
ASELKASMKG
130
LGTDEDSLIE
140
IICSRTNQEL
150
QEINRVYKEM
160
YKTDLEKDII
170
SDTSGDFRKL
180
MVALAKGRRA
190
EDGSVIDYEL
200
IDQDARDLYD
210
AGVKRKGTDV
220
PKWISIMTER
230
SVCHLQKVFE
240
RYKSYSPYDM
250
LESIKKEVKG
260
DLENAFLNLV
270
QCIQNKPLYF
280
ADRLYDSMKG
290
KGTRDKVLIX
300
IMVSRSEVDM
310
LKIRSEFKRK
320
YGKSLYNYIQ
330
QDTKGDYQKA
LLYLCGGDD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:1990665 |
AnxA2-p11 complex |
| Cellular Component |
GO:0005604 |
basement membrane |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005768 |
endosome |
| Cellular Component |
GO:0042470 |
melanosome |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0012506 |
vesicle membrane |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0005544 |
calcium-dependent phospholipid binding |
| Molecular Function |
GO:0008092 |
cytoskeletal protein binding |
| Molecular Function |
GO:0001786 |
phosphatidylserine binding |
| Molecular Function |
GO:0004859 |
phospholipase inhibitor activity |
| Molecular Function |
GO:0044548 |
S100 protein binding |
| Biological Process |
GO:0007155 |
cell adhesion |
| Biological Process |
GO:0044794 |
host-mediated activation of viral process |
| Biological Process |
GO:0010756 |
positive regulation of plasminogen activation |
| Biological Process |
GO:1903902 |
positive regulation of viral life cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.