Search Results
Overview
| Uniprot ID | P19652 |
|---|---|
| Protein Name | Alpha-1-acid glycoprotein 2 |
| Gene Name | ORM2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 182 | YTDWKKDKCEPLEKQ |
Function
Functions as a transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction
Protein Sequence
10
MALSWVLTVL
20
SLLPLLEAQI
30
PLCANLVPVP
40
ITNATLDRIT
50
GKWFYIASAF
60
RNEEYNKSVQ
70
EIQATFFYFT
80
PNKTEDTIFL
90
REYQTRQNQC
100
FYNSSYLNVQ
110
RENGTVSRYE
120
GGREHVAHLL
130
FLRDTKTLMF
140
GSYLDDEKNW
150
GLSFYADKPE
160
TTKEQLGEFY
170
EALDCLCIPR
180
SDVMYTDWKK
190
DKCEPLEKQH
200
EKERKQEEGE
S
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035578 | azurophil granule lumen |
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0031093 | platelet alpha granule lumen |
| Cellular Component | GO:0035580 | specific granule lumen |
| Biological Process | GO:0006953 | acute-phase response |
| Biological Process | GO:0032731 | positive regulation of interleukin-1 beta production |
| Biological Process | GO:0032732 | positive regulation of interleukin-1 production |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:0002682 | regulation of immune system process |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.