Search Results

Overview

Uniprot IDP19823
Protein NameInter-alpha-trypsin inhibitor heavy chain H2
Gene NameITIH2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
374 KTQVADAKRYIEKIQ
487 QDTSSQLKKFYNQVS
488 DTSSQLKKFYNQVST
573 QDFLSKDKHADPDFT
605 LAPTAAAKRRITRSI
809 QRVQISVKKEKVVTI
93 ATTMIQSKVVNNSPQ

Function

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes

Protein Sequence

10 MKRLTCFFIC 20 FFLSEVSGFE 30 IPINGLSEFV 40 DYEDLVELAP 50 GKFQLVAENR 60 RYQRSLPGES 70 EEMMEEVDQV 80 TLYSYKVQST 90 ITSRMATTMI 100 QSKVVNNSPQ 110 PQNVVFDVQI 120 PKGAFISNFS 130 MTVDGKTFRS 140 SIKEKTVGRA 150 LYAQARAKGK 160 TAGLVRSSAL 170 DMENFRTEVN 180 VLPGAKVQFE 190 LHYQEVKWRK 200 LGSYEHRIYL 210 QPGRLAKHLE 220 VDVWVIEPQG 230 LRFLHVPDTF 240 EGHFDGVPVI 250 SKGQQKAHVS 260 FKPTVAQQRI 270 CPNCRETAVD 280 GELVVLYDVK 290 REEKAGELEV 300 FNGYFVHFFA 310 PDNLDPIPKN 320 ILFVIDVSGS 330 MWGVKMKQTV 340 EAMKTILDDL 350 RAEDHFSVID 360 FNQNIRTWRN 370 DLISATKTQV 380 ADAKRYIEKI 390 QPSGGTNINE 400 ALLRAIFILN 410 EANNLGLLDP 420 NSVSLIILVS 430 DGDPTVGELK 440 LSKIQKNVKE 450 NIQDNISLFS 460 LGMGFDVDYD 470 FLKRLSNENH 480 GIAQRIYGNQ 490 DTSSQLKKFY 500 NQVSTPLLRN 510 VQFNYPHTSV 520 TDVTQNNFHN 530 YFGGSEIVVA 540 GKFDPAKLDQ 550 IESVITATSA 560 NTQLVLETLA 570 QMDDLQDFLS 580 KDKHADPDFT 590 RKLWAYLTIN 600 QLLAERSLAP 610 TAAAKRRITR 620 SILQMSLDHH 630 IVTPLTSLVI 640 ENEAGDERML 650 ADAPPQDPSC 660 CSGALYYGSK 670 VVPDSTPSWA 680 NPSPTPVISM 690 LAQGSQVLES 700 TPPPHVMRVE 710 NDPHFIIYLP 720 KSQKNICFNI 730 DSEPGKILNL 740 VSDPESGIVV 750 NGQLVGAKKP 760 NNGKLSTYFG 770 KLGFYFQSED 780 IKIEISTETI 790 TLSHGSSTFS 800 LSWSDTAQVT 810 NQRVQISVKK 820 EKVVTITLDK 830 EMSFSVLLHR 840 VWKKHPVNVD 850 FLGIYIPPTN 860 KFSPKAHGLI 870 GQFMQEPKIH 880 IFNERPGKDP 890 EKPEASMEVK 900 GQKLIITRGL 910 QKDYRTDLVF 920 GTDVTCWFVH 930 NSGKGFIDGH 940 YKDYFVPQLY SFLKRP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0072562 blood microparticle
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Molecular Function GO:0004866 endopeptidase inhibitor activity
Molecular Function GO:0005540 hyaluronic acid binding
Molecular Function GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process GO:0030212 hyaluronan metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.