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Overview

Uniprot IDP19827
Protein NameInter-alpha-trypsin inhibitor heavy chain H1
Gene NameITIH1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
222 ELAAQTIKKSFSGKK
312 GQKVKQTKEALLKIL
418 TDRSQILKNVRNAIR

Function

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes

Protein Sequence

10 MDGAMGPRGL 20 LLCMYLVSLL 30 ILQAMPALGS 40 ATGRSKSSEK 50 RQAVDTAVDG 60 VFIRSLKVNC 70 KVTSRFAHYV 80 VTSQVVNTAN 90 EAREVAFDLE 100 IPKTAFISDF 110 AVTADGNAFI 120 GDIKDKVTAW 130 KQYRKAAISG 140 ENAGLVRASG 150 RTMEQFTIHL 160 TVNPQSKVTF 170 QLTYEEVLKR 180 NHMQYEIVIK 190 VKPKQLVHHF 200 EIDVDIFEPQ 210 GISKLDAQAS 220 FLPKELAAQT 230 IKKSFSGKKG 240 HVLFRPTVSQ 250 QQSCPTCSTS 260 LLNGHFKVTY 270 DVSRDKICDL 280 LVANNHFAHF 290 FAPQNLTNMN 300 KNVVFVIDIS 310 GSMRGQKVKQ 320 TKEALLKILG 330 DMQPGDYFDL 340 VLFGTRVQSW 350 KGSLVQASEA 360 NLQAAQDFVR 370 GFSLDEATNL 380 NGGLLRGIEI 390 LNQVQESLPE 400 LSNHASILIM 410 LTDGDPTEGV 420 TDRSQILKNV 430 RNAIRGRFPL 440 YNLGFGHNVD 450 FNFLEVMSME 460 NNGRAQRIYE 470 DHDATQQLQG 480 FYSQVAKPLL 490 VDVDLQYPQD 500 AVLALTQNHH 510 KQYYEGSEIV 520 VAGRIADNKQ 530 SSFKADVQAH 540 GEGQEFSITC 550 LVDEEEMKKL 560 LRERGHMLEN 570 HVERLWAYLT 580 IQELLAKRMK 590 VDREERANLS 600 SQALQMSLDY 610 GFVTPLTSMS 620 IRGMADQDGL 630 KPTIDKPSED 640 SPPLEMLGPR 650 RTFVLSALQP 660 SPTHSSSNTQ 670 RLPDRVTGVD 680 TDPHFIIHVP 690 QKEDTLCFNI 700 NEEPGVILSL 710 VQDPNTGFSV 720 NGQLIGNKAR 730 SPGQHDGTYF 740 GRLGIANPAT 750 DFQLEVTPQN 760 ITLNPGFGGP 770 VFSWRDQAVL 780 RQDGVVVTIN 790 KKRNLVVSVD 800 DGGTFEVVLH 810 RVWKGSSVHQ 820 DFLGFYVLDS 830 HRMSARTHGL 840 LGQFFHPIGF 850 EVSDIHPGSD 860 PTKPDATMVV 870 RNRRLTVTRG 880 LQKDYSKDPW 890 HGAEVSCWFI 900 HNNGAGLIDG 910 AYTDYIVPDI F

Gene Ontology

Classification GO ID Description
Cellular Component GO:0072562 blood microparticle
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0030246 carbohydrate binding
Molecular Function GO:0005540 hyaluronic acid binding
Molecular Function GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process GO:0030212 hyaluronan metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.