Search Results
Overview
| Uniprot ID | P19836 |
|---|---|
| Protein Name | Choline-phosphate cytidylyltransferase A |
| Gene Name | Pcyt1a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 228 | LQRGYTAKELNVSFI |
| 238 | NVSFINEKKYHLQER |
| 239 | VSFINEKKYHLQERV |
| 266 | KSKEFVQKVEEKSID |
| 8 | MDAQSSAKVNSRKRR |
Function
Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis
Protein Sequence
10
MDAQSSAKVN
20
SRKRRKEVPG
30
PNGATEEDGI
40
PSKVQRCAVG
50
LRQPAPFSDE
60
IEVDFSKPYV
70
RVTMEEACRG
80
TPCERPVRVY
90
ADGIFDLFHS
100
GHARALMQAK
110
NLFPNTYLIV
120
GVCSDELTHN
130
FKGFTVMNEN
140
ERYDAVQHCR
150
YVDEVVRNAP
160
WTLTPEFLAE
170
HRIDFVAHDD
180
IPYSSAGSDD
190
VYKHIKEAGM
200
FAPTQRTEGI
210
STSDIITRIV
220
RDYDVYARRN
230
LQRGYTAKEL
240
NVSFINEKKY
250
HLQERVDKVK
260
KKVKDVEEKS
270
KEFVQKVEEK
280
SIDLIQKWEE
290
KSREFIGSFL
300
EMFGPEGALK
310
HMLKEGKGRM
320
LQAISPKQSP
330
SSSPTHERSP
340
SPSFRWPFSG
350
KTSPSSSPAS
360
LSRCKAVTCD
ISEDEED
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0019898 | extrinsic component of membrane |
| Cellular Component | GO:0042587 | glycogen granule |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0004105 | choline-phosphate cytidylyltransferase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0140678 | molecular function inhibitor activity |
| Molecular Function | GO:0031210 | phosphatidylcholine binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0042100 | B cell proliferation |
| Biological Process | GO:0006657 | CDP-choline pathway |
| Biological Process | GO:0045190 | isotype switching |
| Biological Process | GO:0006656 | phosphatidylcholine biosynthetic process |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.