Search Results
Overview
| Uniprot ID | P19971 |
|---|---|
| Protein Name | Thymidine phosphorylase |
| Gene Name | TYMP |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 115 | WRQQLVDKHSTGGVG |
| 275 | AALTAMDKPLGRCVG |
Function
May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro
Protein Sequence
10
MAALMTPGTG
20
APPAPGDFSG
30
EGSQGLPDPS
40
PEPKQLPELI
50
RMKRDGGRLS
60
EADIRGFVAA
70
VVNGSAQGAQ
80
IGAMLMAIRL
90
RGMDLEETSV
100
LTQALAQSGQ
110
QLEWPEAWRQ
120
QLVDKHSTGG
130
VGDKVSLVLA
140
PALAACGCKV
150
PMISGRGLGH
160
TGGTLDKLES
170
IPGFNVIQSP
180
EQMQVLLDQA
190
GCCIVGQSEQ
200
LVPADGILYA
210
ARDVTATVDS
220
LPLITASILS
230
KKLVEGLSAL
240
VVDVKFGGAA
250
VFPNQEQARE
260
LAKTLVGVGA
270
SLGLRVAAAL
280
TAMDKPLGRC
290
VGHALEVEEA
300
LLCMDGAGPP
310
DLRDLVTTLG
320
GALLWLSGHA
330
GTQAQGAARV
340
AAALDDGSAL
350
GRFERMLAAQ
360
GVDPGLARAL
370
CSGSPAERRQ
380
LLPRAREQEE
390
LLAPADGTVE
400
LVRALPLALV
410
LHELGAGRSR
420
AGEPLRLGVG
430
AELLVDVGQR
440
LRRGTPWLRV
450
HRDGPALSGP
460
QSRALQEALV
470
LSDRAPFAAP
480
SPFAELVLPP
QQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0004645 | 1,4-alpha-oligoglucan phosphorylase activity |
| Molecular Function | GO:0008083 | growth factor activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0009032 | thymidine phosphorylase activity |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0006935 | chemotaxis |
| Biological Process | GO:0046074 | dTMP catabolic process |
| Biological Process | GO:0006206 | pyrimidine nucleobase metabolic process |
| Biological Process | GO:0006213 | pyrimidine nucleoside metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.