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Overview

Uniprot IDP20020
Protein NamePlasma membrane calcium-transporting ATPase 1
Gene NameATP2B1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1070 TSRLKFLKEAGHGTQ

Function

Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis (PubMed:35358416). Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (PubMed:29104511). May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles

Protein Sequence

10 MGDMANNSVA 20 YSGVKNSLKE 30 ANHDGDFGIT 40 LAELRALMEL 50 RSTDALRKIQ 60 ESYGDVYGIC 70 TKLKTSPNEG 80 LSGNPADLER 90 REAVFGKNFI 100 PPKKPKTFLQ 110 LVWEALQDVT 120 LIILEIAAIV 130 SLGLSFYQPP 140 EGDNALCGEV 150 SVGEEEGEGE 160 TGWIEGAAIL 170 LSVVCVVLVT 180 AFNDWSKEKQ 190 FRGLQSRIEQ 200 EQKFTVIRGG 210 QVIQIPVADI 220 TVGDIAQVKY 230 GDLLPADGIL 240 IQGNDLKIDE 250 SSLTGESDHV 260 KKSLDKDPLL 270 LSGTHVMEGS 280 GRMVVTAVGV 290 NSQTGIIFTL 300 LGAGGEEEEK 310 KDEKKKEKKN 320 KKQDGAIENR 330 NKAKAQDGAA 340 MEMQPLKSEE 350 GGDGDEKDKK 360 KANLPKKEKS 370 VLQGKLTKLA 380 VQIGKAGLLM 390 SAITVIILVL 400 YFVIDTFWVQ 410 KRPWLAECTP 420 IYIQYFVKFF 430 IIGVTVLVVA 440 VPEGLPLAVT 450 ISLAYSVKKM 460 MKDNNLVRHL 470 DACETMGNAT 480 AICSDKTGTL 490 TMNRMTVVQA 500 YINEKHYKKV 510 PEPEAIPPNI 520 LSYLVTGISV 530 NCAYTSKILP 540 PEKEGGLPRH 550 VGNKTECALL 560 GLLLDLKRDY 570 QDVRNEIPEE 580 ALYKVYTFNS 590 VRKSMSTVLK 600 NSDGSYRIFS 610 KGASEIILKK 620 CFKILSANGE 630 AKVFRPRDRD 640 DIVKTVIEPM 650 ASEGLRTICL 660 AFRDFPAGEP 670 EPEWDNENDI 680 VTGLTCIAVV 690 GIEDPVRPEV 700 PDAIKKCQRA 710 GITVRMVTGD 720 NINTARAIAT 730 KCGILHPGED 740 FLCLEGKDFN 750 RRIRNEKGEI 760 EQERIDKIWP 770 KLRVLARSSP 780 TDKHTLVKGI 790 IDSTVSDQRQ 800 VVAVTGDGTN 810 DGPALKKADV 820 GFAMGIAGTD 830 VAKEASDIIL 840 TDDNFTSIVK 850 AVMWGRNVYD 860 SISKFLQFQL 870 TVNVVAVIVA 880 FTGACITQDS 890 PLKAVQMLWV 900 NLIMDTLASL 910 ALATEPPTES 920 LLLRKPYGRN 930 KPLISRTMMK 940 NILGHAFYQL 950 VVVFTLLFAG 960 EKFFDIDSGR 970 NAPLHAPPSE 980 HYTIVFNTFV 990 LMQLFNEINA 1000 RKIHGERNVF 1010 EGIFNNAIFC 1020 TIVLGTFVVQ 1030 IIIVQFGGKP 1040 FSCSELSIEQ 1050 WLWSIFLGMG 1060 TLLWGQLIST 1070 IPTSRLKFLK 1080 EAGHGTQKEE 1090 IPEEELAEDV 1100 EEIDHAEREL 1110 RRGQILWFRG 1120 LNRIQTQIRV 1130 VNAFRSSLYE 1140 GLEKPESRSS 1150 IHNFMTHPEF 1160 RIEDSEPHIP 1170 LIDDTDAEDD 1180 APTKRNSSPP 1190 PSPNKNNNAV 1200 DSGIHLTIEM 1210 NKSATSSSPG 1220 SPLHSLETSL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0001772 immunological synapse
Cellular Component GO:0016020 membrane
Cellular Component GO:0098684 photoreceptor ribbon synapse
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0042734 presynaptic membrane
Cellular Component GO:0030672 synaptic vesicle membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0015085 calcium ion transmembrane transporter activity
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0140678 molecular function inhibitor activity
Molecular Function GO:0005388 P-type calcium transporter activity
Biological Process GO:1990034 calcium ion export across plasma membrane
Biological Process GO:0034220 monoatomic ion transmembrane transport
Biological Process GO:0001818 negative regulation of cytokine production
Biological Process GO:0051481 negative regulation of cytosolic calcium ion concentration
Biological Process GO:0030501 positive regulation of bone mineralization
Biological Process GO:0051928 positive regulation of calcium ion transport
Biological Process GO:0008217 regulation of blood pressure
Biological Process GO:1903779 regulation of cardiac conduction
Biological Process GO:1900076 regulation of cellular response to insulin stimulus
Biological Process GO:0051480 regulation of cytosolic calcium ion concentration
Biological Process GO:0003056 regulation of vascular associated smooth muscle contraction

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.