Search Results
Overview
| Uniprot ID | P20070 |
|---|---|
| Protein Name | NADH-cytochrome b5 reductase 3 |
| Gene Name | Cyb5r3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 115 | LVVKVYFKDTHPKFP |
| 164 | FAIRADKKSNPVVRT |
| 42 | TLENPDIKYPLRLID |
| 50 | YPLRLIDKEIISHDT |
Function
Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor
Protein Sequence
10
MGAQLSTLSR
20
VVLSPVWFVY
30
SLFMKLFQRS
40
SPAITLENPD
50
IKYPLRLIDK
60
EIISHDTRRF
70
RFALPSPQHI
80
LGLPIGQHIY
90
LSTRIDGNLV
100
IRPYTPVSSD
110
DDKGFVDLVV
120
KVYFKDTHPK
130
FPAGGKMSQY
140
LENMNIGDTI
150
EFRGPNGLLV
160
YQGKGKFAIR
170
ADKKSNPVVR
180
TVKSVGMIAG
190
GTGITPMLQV
200
IRAVLKDPND
210
HTVCYLLFAN
220
QSEKDILLRP
230
ELEELRNEHS
240
SRFKLWYTVD
250
KAPDAWDYSQ
260
GFVNEEMIRD
270
HLPPPGEETL
280
ILMCGPPPMI
290
QFACLPNLER
300
VGHPKERCFT
F
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005811 | lipid droplet |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:1903958 | nitric-oxide synthase complex |
| Molecular Function | GO:0043531 | ADP binding |
| Molecular Function | GO:0016208 | AMP binding |
| Molecular Function | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H |
| Molecular Function | GO:0090524 | cytochrome-b5 reductase activity, acting on NADH |
| Molecular Function | GO:0071949 | FAD binding |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0051287 | NAD binding |
| Biological Process | GO:0006695 | cholesterol biosynthetic process |
| Biological Process | GO:0006809 | nitric oxide biosynthetic process |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.