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Overview

Uniprot IDP20073
Protein NameAnnexin A7
Gene NameANXA7
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
199 EILRKAMKGFGTDEQ
268 YDAWSLRKAMQGAGT
430 ERLYYAMKGAGTDDS

Function

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis

Protein Sequence

10 MSYPGYPPTG 20 YPPFPGYPPA 30 GQESSFPPSG 40 QYPYPSGFPP 50 MGGGAYPQVP 60 SSGYPGAGGY 70 PAPGGYPAPG 80 GYPGAPQPGG 90 APSYPGVPPG 100 QGFGVPPGGA 110 GFSGYPQPPS 120 QSYGGGPAQV 130 PLPGGFPGGQ 140 MPSQYPGGQP 150 TYPSQINTDS 160 FSSYPVFSPV 170 SLDYSSEPAT 180 VTQVTQGTIR 190 PAANFDAIRD 200 AEILRKAMKG 210 FGTDEQAIVD 220 VVANRSNDQR 230 QKIKAAFKTS 240 YGKDLIKDLK 250 SELSGNMEEL 260 ILALFMPPTY 270 YDAWSLRKAM 280 QGAGTQERVL 290 IEILCTRTNQ 300 EIREIVRCYQ 310 SEFGRDLEKD 320 IRSDTSGHFE 330 RLLVSMCQGN 340 RDENQSINHQ 350 MAQEDAQRLY 360 QAGEGRLGTD 370 ESCFNMILAT 380 RSFPQLRATM 390 EAYSRMANRD 400 LLSSVSREFS 410 GYVESGLKTI 420 LQCALNRPAF 430 FAERLYYAMK 440 GAGTDDSTLV 450 RIVVTRSEID 460 LVQIKQMFAQ 470 MYQKTLGTMI 480 AGDTSGDYRR LLLAIVGQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0097208 alveolar lamellar body
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0012506 vesicle membrane
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0005544 calcium-dependent phospholipid binding
Molecular Function GO:0048306 calcium-dependent protein binding
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0001786 phosphatidylserine binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006914 autophagy
Biological Process GO:0030855 epithelial cell differentiation
Biological Process GO:0061025 membrane fusion
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0051592 response to calcium ion
Biological Process GO:1904627 response to phorbol 13-acetate 12-myristate

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.